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PE anti-mouse/human CD11b Antibody

Pricing & Availability
Clone
M1/70 (See other available formats)
Regulatory Status
RUO
Other Names
αM integrin, Mac-1, Mo1, CR3, Ly-40, C3biR, ITGAM
Isotype
Rat IgG2b, κ
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Product Citations
publications
M170_PE_042706
C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) PE (filled histogram) or rat IgG2b, κ PE isotype control (open histogram) (gated on total cells).
  • M170_PE_042706
    C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) PE (filled histogram) or rat IgG2b, κ PE isotype control (open histogram) (gated on total cells).
  • M170_PE_CD11b_Antibody_IHC_031413
    Fixed whole mount mouse spleen was stained with Alexa Fluor® 488 F4/80 (red) (clone BM8), Brilliant Violet 421™ CD3ε (green) (clone 145-2C11), and PE CD11b (blue) (clone M1/70). Isotype controls at the same concentrations were used for the negative control. Cells were mounted in Prolong Gold and imaged with a Leica SP8 confocal. Image courtesy of Grzegorz Chodaczek and Zbigniew Mikulski at LIAI.
Compare all formats See PE spectral data See more IHC data...
Cat # Size Price Save
101207 50 µg ¥12,320
101208 200 µg ¥30,000
Description

CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse, Human, Cynomolgus, Rhesus
Reported Reactivity
Chimpanzee, Baboon, Rabbit
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C57BL/10 splenocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/mL
Storage & Handling
The CD11b antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
IHC - Verified
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone M1/70 has been verified for immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F).

Additional reported applications (for relevant formats of this clone) include: immunoprecipitation1,4, in vitro blocking3,9,12, depletion2,8, immunofluorescence microscopy6,7,10, immunohistochemistry of acetone-fixed frozen sections5,11-13, and spatial biology (IBEX)35,36. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) (Cat. No. 101248).

Additional Product Notes

View more applications data for this product in our Scientific Poster Library.

Application References

(PubMed link indicates BioLegend citation)
  1. Springer T, et al. 1978. Eur. J. Immunol. 8:539. (IP)
  2. Ault K and Springer T. 1981. J. Immunol. 126:359. (Deplete)
  3. Springer TA, et al. 1982. Immunol. Rev. 68:171. (Block)
  4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. (IP)
  5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112. (IHC)
  6. Noel GJ, et al. 1990. J. Clin. Invest. 85:208. (IF)
  7. Allen LA and Aderem A. 1996. J. Exp. Med. 184:627 (IF)
  8. D'Amico A and Wu L. 2003. J. Exp. Med. 198:293. (Deplete)
  9. Brickson SJ, et al. 2003. Appl Physiol. 95:969. (Block)
  10. Clatworthy MR and Smith KG. 2004. J. Exp. Med. 199:717. (IF)
  11. Hata H, et al. 2004. J. Clin. Invest. 114:582. (IHC)
  12. Zhang Y, et al. 2002. J. Immunol. 168:3088. (IHC)
  13. Iwasaki A and Kelsall BL. 2001. J. Immunol. 166:4884 (IHC, FC)
  14. Tailleux L. 2003. J. Exp. Med. 197:121. (Block, FC)
  15. Olver S, et al. 2006. Cancer Research 66:571. (FC)
  16. Tan SL, et al. 2006. J. Immunol. 176:2872. (FC) PubMed
  17. Ponomarev ED, et al. 2006. J. Immunol. 176:1402. (FC)
  18. Dzhagalov I, et al. 2007. Blood 109:1620. (FC)
  19. Fazilleau N, et al. 2007. Nature Immunol. 8:753.
  20. Rasmussen JW, et al. 2006. Infect. Immun.74:6590. PubMed
  21. Napimoga MH, et al. 2008. J. Immunol. 180:609. PubMed
  22. Elqaraz-Carmon V, et al. 2008. J. Lipid. Res. 49:1894. PubMed
  23. Kim DD, et al. 2008. Blood 112:1109. PubMed
  24. Guo Y, et al. 2008. Blood 112:480. PubMed
  25. Norian LA, et al. 2009. Cancer Res. 69:3086. (FC) PubMed
  26. Baumgartner CK, et al. 2010. J. Immunol. 184:573. PubMed
  27. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  28. Whiteland J, et al. 1995. J. Histochem. Cytochem. 43:313. (IHC)
  29. Weber GF, et al. 2014. J Exp Med. 211:1243. PubMed
  30. Ashok A, et al. 2015. Toxicol Sci. 143:64. PubMed
  31. Price PJ, et al. 2015. J Immunol. 194:1164. PubMed
  32. Doni A, et al. 2015. J Exp Med. 212:905. PubMed
  33. Ferreira R, et al. 2016. J Infect Dis. 213: 669 - 673. PubMed
  34. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  35. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  36. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Grigsby SM, et al. 2021. Cancers (Basel). 13:. PubMed
  2. Kuo PC, et al. 2021. Brain Commun. 3:fcab187. PubMed
  3. Zhao D, et al. 2021. Innate Immun. 27:533. PubMed
  4. Rosina M, et al. 2022. Cell Metab. 34:533. PubMed
  5. Nigam S, et al. 2020. Mol Imaging Biol. 22:685. PubMed
  6. Hu K, et al. 2022. J Extracell Vesicles. 11:e12199. PubMed
  7. Ho YH, et al. 2019. Cell Stem Cell. 25:407. PubMed
  8. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  9. Kisielow J, et al. 2019. Nat Immunol. 1.286111111. PubMed
  10. Li A, et al. 2020. Oncol Lett. 1.899305556. PubMed
  11. Guo H, Cooper S, Friedman A, et al. 2017. PLoS One. 10.1371/journal.pone.0150809. PubMed
  12. Chida J, et al. 2020. PLoS Pathog. 16:e1008823. PubMed
  13. Guo Y, et al. 2021. Exp Ther Med. 353:21. PubMed
  14. Schloss MJ, et al. 2022. Nat Immunol. 23:605. PubMed
  15. Yan F, et al. 2022. Cancer Discov. 12:792. PubMed
  16. Lee S, et al. 2021. JCI Insight. 6:. PubMed
  17. Zhao X, et al. 2022. Front Mol Biosci. 9:786864. PubMed
  18. Deng Y, et al. 2021. Acta Pharmacol Sin. 42:149. PubMed
  19. Pan J, et al. 2021. Mol Ther Nucleic Acids. 26:970. PubMed
  20. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  21. Jones NM, et al. 2019. BMC Cancer. 1.127777778. PubMed
  22. Wu N, et al. 2020. Cell Rep. 30:1129. PubMed
  23. Bhatt K, et al. 2018. mSphere. 3:e00352. PubMed
  24. Baryawno N et al. 2019. Cell. 177(7):1915-1932 . PubMed
  25. Abels ER et al. 2019. Cell Rep. 28(12):3105-3119 . PubMed
  26. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  27. Prajeeth C,et al. 2017. J Neuroinflammation.. 10.1186/s12974-017-0978-3. PubMed
  28. Lei G, et al. 2016. Antimicrob Agents Chemother. 60: 1289 - 1297. PubMed
  29. Sauter M, et al. 2022. iScience. 25:103677. PubMed
  30. Conforti A, et al. 2021. PLoS One. 16:e0259894. PubMed
  31. Götz P, et al. 2022. Int J Mol Sci. 23:. PubMed
  32. Adachi Y, et al. 2022. Nat Commun. 13:5117. PubMed
  33. Gonçalves NP, et al. 2017. J Neuroinflammation. 14:115. PubMed
  34. Yamauchi T et al. 2018. Cancer cell. 33(3):386-400 . PubMed
  35. Xiao X, et al. 2020. J Hematol Oncol. 0.597222222. PubMed
  36. Elkabets M, et al. 2009. J Immunol. 182:4874. PubMed
  37. Li X, et al. 2015. Proc Natl Acad Sci U S A. 112:6080. PubMed
  38. Zhang Y, et al. 2020. Oncol Lett. 1.053472222. PubMed
  39. Dumas SJ, et al. 2021. STAR Protocols. 2(3):100523. PubMed
  40. Zhang Z, et al. 2020. J Immunol. 204:3400. PubMed
  41. Shears RK, et al. 2020. J Allergy Clin Immunol. 145:1272. PubMed
  42. Chen X, et al. 2021. Cell Death Differ. 28:1237. PubMed
  43. Stolp B, et al. 2022. Cell Rep. 38:110387. PubMed
  44. Craver BM, et al. 2020. Blood Adv. 4:312. PubMed
  45. Hiraishi Y, et al. 2018. Sci Rep. 8:18052. PubMed
  46. Wu R, et al. 2019. J Cell Mol Med. 24:1684. PubMed
  47. Llewellyn GN, et al. 2018. J Neurovirol. 24:192. PubMed
  48. Sun Y et al. 2018. Cancer cell. 34(4):643-658 . PubMed
  49. Forte E, et al. 2020. J Cell Mol Med. . PubMed
  50. Earnest JT, et al. 2021. Cell Reports. 35(1):108962. PubMed
  51. Jard T, et al. 2020. Cell Stem Cell. 27(4):646-662.e7. PubMed
  52. Forte D, et al. 2020. Cell Metab. 32:829. PubMed
  53. Coppo M, et al. 2016. Nat Commun. 7:12254. PubMed
  54. Wang X, et al. 2016. PLoS Pathog. 12: 1005367. PubMed
  55. Joseph R, et al. 2021. Br J Cancer. 125:176. PubMed
  56. Park JA, et al. 2021. J Hematol Oncol. 14:142. PubMed
  57. Wang Y, et al. 2022. Acta Pharm Sin B. 12:262. PubMed
  58. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  59. Chen F, et al. 2022. Evid Based Complement Alternat Med. 2022:1240242. PubMed
  60. Xu F, et al. 2022. Cell Death Discov. 8:142. PubMed
  61. Turkowski K, et al. 2017. Glia. 10.1002/glia.23234. PubMed
  62. Wiese A, et al. 2017. PLoS One. 10.1371/journal.pone.0184956. PubMed
  63. Hengyou Weng et al. 2018. Cell stem cell. 22(2):191-205 . PubMed
  64. Nakagawa S et al. 2017. Cell host & microbe. 22(5):667-677 . PubMed
  65. Swidergall M, et al. 2019. Cell Rep. 28:423. PubMed
  66. Ganeshan K et al. 2019. Cell. 177(2):399-413 . PubMed
  67. LaFleur MW, et al. 2019. Nat Immunol. 20:1335. PubMed
  68. Tsuchiya N, et al. 2020. Cell Reports. 29(1):162-175.e9.. PubMed
  69. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  70. Price J, et al. 2015. Diabetes. 64: 3521 - 3531. PubMed
  71. Kalucka J, et al. 2020. Cell. 764:180. PubMed
  72. Li K, et al. 2022. J Immunother Cancer. 10:. PubMed
  73. Hongu T, et al. 2022. Nat Cancer. 3:486. PubMed
  74. Rogawski DS, et al. 2021. Nat Commun. 12:2792. PubMed
  75. Trenevska I, et al. 2021. PLoS One. 16:e0249967. PubMed
  76. Gordon RA, et al. 2020. PLoS One. 15:e0226396. PubMed
  77. Zhang Z, et al. 2021. Oncoimmunology. 10:1912472. PubMed
  78. Pan J, et al. 2020. J Neuroinflammation. 17:97. PubMed
  79. Paraiso HC, et al. 2018. J Neuroinflammation. 0.694444444. PubMed
  80. Pan W et al. 2017. Immunity. 47(2):284-297 . PubMed
  81. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  82. Hammond TR, et al. 2019. Immunity. 50:253. PubMed
  83. Wang C, et al. 2017. J Immunol. 10.4049/jimmunol.1700671. PubMed
  84. Haugh KA, et al. 2021. eLife. 0.416666666666667. PubMed
  85. Perner C, et al. 2020. Immunity. 53(5):1063-1077.e7. PubMed
  86. Endo Y, et al. 2020. FASEB J. 34:16086. PubMed
  87. Diao N, et al. 2016. Sci Rep. 6:34672. PubMed
  88. Huang L, et al. 2016. J Biol Chem. 291: 6232 - 6244. PubMed
  89. Sharma S, et al. 2015. J Immunol. 194:5529. PubMed
  90. Cheng K, et al. 2021. Nat Commun. 12:2041. PubMed
  91. Zheng Y, et al. 2022. Front Pharmacol. 12:816032. PubMed
  92. Dane EL, et al. 2022. Nat Mater. 21:710. PubMed
  93. Guo W, et al. 2022. J Immunother Cancer. 10:. PubMed
  94. Zhang X, et al. 2022. Cells. 11:. PubMed
  95. An J,et al. 2017. Sci Rep.. 10.1038/s41598-017-13629-0. PubMed
  96. Wang L, et al. 2017. Front Immunol.. 10.3389/fimmu.2017.01754. PubMed
  97. Kunimoto H, et al. 2018. Cancer Cell. 33:44. PubMed
  98. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  99. Zhang S, et al. 2019. Mol Med Rep. 19:5377. PubMed
  100. Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
  101. Riffelmacher T et al. 2017. Immunity. 47(3):466-480 . PubMed
  102. Nakaya M, et al. 2017. J Clin Invest. 127:383. PubMed
  103. Mayo L, et al. 2008. J Immunol. 181:92. PubMed
  104. Xiao Z, et al. 2015. Cancer Lett. 360:302. PubMed
  105. Donley DW, et al. 2021. PLOS ONE. 16(5):e0250606. PubMed
  106. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  107. Ratitong B, et al. 2021. Cell Reports. 35(7):109139. PubMed
  108. Kotaki R, et al. 2020. Sci Rep. 10:13554. PubMed
  109. Wu L, et al. 2022. Theranostics. 12:842. PubMed
  110. Ajina R, et al. 2021. Cancer Immunol Res. 9:386. PubMed
  111. Bertino P, et al. 2019. Oncoimmunology. 8:1601482. PubMed
  112. Keshavarz M, et al. 2020. Virol J. 17:64. PubMed
  113. He L, et al. 2019. iScience. 0.790972222. PubMed
  114. Frazier T, et al. 2018. Adipocyte. 0.41875. PubMed
  115. Deng Z, et al. 2017. Oncogene. 36:639. PubMed
  116. Liu D et al. 2019. Immunity. 51(1):64-76 . PubMed
  117. Anstine L,et al. 2017. J Am Heart Assoc.. 10.1161/JAHA.117.007097. PubMed
  118. Jin R, et al. 2020. Mol Cancer Ther. . PubMed
  119. Nguyen TKT, et al. 2020. Am J Pathol. 286:190. PubMed
  120. Gereke M, et al. 2012. J Vis Exp. 70: 4322. PubMed
  121. Pang D, et al. 2015. Clin Transl Immunology. 4: e41. PubMed
  122. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  123. Hildebrand KM, et al. 2021. PLoS One. 16:e0253864. PubMed
  124. Du Y, et al. 2022. Nat Commun. 13:231. PubMed
  125. Malekghasemi S, et al. 2020. Cell Biol Int. 44:2031. PubMed
  126. Hönes J, et al. 2017. Sci Rep. . 10.1038/s41598-017-15866-9. PubMed
  127. Niemann J, et al. 2019. Nat Commun. 10:3236. PubMed
  128. Hou M, et al. 2020. Stem Cell Res Ther. 11:55. PubMed
  129. Jaworska K, et al. 2015. J Immunol. 194:325. PubMed
  130. Chen Y, et al. 2015. PLoS One. 10: 0135217. PubMed
  131. Li L, et al. 2015. J Am Soc Nephrol. 26: 2183-2197. PubMed
  132. Souza COS, et al. 2021. iScience. 24(6):102548. PubMed
  133. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  134. Baik JE, et al. 2022. Clin Transl Med. 12:e758. PubMed
  135. Di Martino L, et al. 2021. Cell Mol Gastroenterol Hepatol. 13:901. PubMed
  136. Zhang C, et al. 2022. Nat Commun. 13:3468. PubMed
  137. Lin S, et al. 2022. Nat Commun. 13:3301. PubMed
  138. Ye P, et al. 2022. Front Cardiovasc Med. 8:810477. PubMed
  139. Frodermann V, et al. 2019. Nat Med. 25:1761. PubMed
  140. Luong-Gardiol N, et al. 2019. Cancer Cell. 35:649. PubMed
  141. Murray C, et al. 2018. Lab Chip. 18:2396. PubMed
  142. Han D, et al. 2021. J Immunol Res. 6688053:2021. PubMed
  143. Nguyen GT, et al. 2021. iScience. 24(8):102871. PubMed
  144. Garg M, et al. 2021. Cell Reports. 34(6):108736. PubMed
  145. Cao DY, et al. 2020. J Biol Chem. 295:1369. PubMed
  146. Moorlag SJCFM, et al. 2020. Cell Rep. 33:108387. PubMed
  147. Koshida R, et al. 2015. Biochem Biophys Res Commun. 463: 109-115. PubMed
  148. Textor A, et al. 2014. Cancer Res. 74:6769. PubMed
  149. Haas MS, et al. 2020. Mol Cancer Res. 19:717. PubMed
  150. Jorapur A, et al. 2022. PLoS Pathog. 18:e1010200. PubMed
  151. Yang Y, et al. 2022. Elife. 11:. PubMed
  152. Bolkhovitina EL, et al. 2022. Int J Mol Sci. 23: . PubMed
  153. Colombo M, et al. 2022. iScience. 25:105042. PubMed
  154. Xiang W, et al. 2018. Nat Commun. 9:2574. PubMed
  155. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  156. He J, et al. 2019. J Clin Invest. 130. PubMed
  157. Huang Y, et al. 2019. Cancer Cell. 35:677. PubMed
  158. Ruiz de Azua I, et al. 2017. J Clin Invest. 127:4148. PubMed
  159. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  160. Liang J, et al. 2020. Sci Adv. 6:eabc3646. PubMed
  161. Kan X, et al. 2015. Cardiovasc Res. 10.1093/cvr/cvv255. PubMed
  162. Mizuno T, et al. 2017. Sci Rep. 7:42714. PubMed
  163. Holokai L, et al. 2020. Cancers (Basel). 12:00. PubMed
  164. Perez-Garcia CG, et al. 2022. Mol Ther Nucleic Acids. 28:87. PubMed
  165. Uslu M, et al. 2020. J Cell Physiol. 235:9644. PubMed
  166. Zhai K, et al. 2021. Nat Cancer. 2:1136. PubMed
  167. Chiang HY, et al. 2022. Nat Commun. 13:874. PubMed
  168. Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
  169. Bermejo-Jambrina M, et al. 2021. EMBO J. 40:e106765. PubMed
  170. Henrich IC, et al. 2021. Cancer Res. 81:2171. PubMed
  171. Staschke K, et al. 2009. J Immunol. 183:568. PubMed
  172. Challa TD, et al. 2020. Cell Reports. 30(10):3424-3433. PubMed
  173. Minuesa G, et al. 2019. Nat Commun. 10:2691. PubMed
  174. Zhou J, et al. 2019. Nat Commun. 10:2427. PubMed
  175. Kubota S, et al. 2019. Nat Commun. 10:1653. PubMed
  176. Wang Q, et al. 2018. Int J Biol Sci. 14:147. PubMed
  177. Koikawa K, et al. 2021. Cell. 184:4753. PubMed
  178. Sokol L, et al. 2021. STAR Protocols. 2(2):100489. PubMed
  179. Yamakawa D, et al. 2021. Cell Reports. 34(10):108817. PubMed
  180. Troutman TD, et al. 2021. STAR Protocols. 2(1):100363. PubMed
  181. Wang L, et al. 2012. PLoS One. 7:e40056. PubMed
  182. Roy AG, et al. 2021. Int J Mol Sci. 22:. PubMed
  183. Liu S, et al. 2022. J Neuroinflammation. 19:35. PubMed
  184. Xiao Y, et al. 2022. Nat Commun. 13:758. PubMed
  185. Ali S, et al. 2021. PLoS One. 16:e0246646. PubMed
  186. Nuro-Gyina PK, et al. 2021. J Immunol. 207:868. PubMed
  187. Babagana M, et al. 2021. Aging (Albany NY). 13:19207. PubMed
  188. Li Q, et al. 2022. Front Cardiovasc Med. 9:872102. PubMed
  189. Dungan CM, et al. 2022. Aging Cell. 21:e13528. PubMed
  190. Hsu Y, et al. 2017. Biochem Biophys Res Commun.. 10.1016/j.bbrc.2017.10.067. PubMed
  191. Subramanian K, et al. 2019. Nat Microbiol. 4:62. PubMed
  192. Yang BH, et al. 2020. Cell Reports. 27(12):3629-3645.e6.. PubMed
  193. Gomez–Ospina N, et al. 2019. Nat Commun. 3.225694444. PubMed
  194. Tao Z, et al. 2019. Clin Cancer Res. 25:1113. PubMed
  195. Tan S, et al. 2006. J Immunol. 176:2872. PubMed
  196. Langhauser F, et al. 2014. Stroke. 45:1799. PubMed
  197. Garcia-Bonilla L, et al. 2014. J Immunol. 193:2531. PubMed
  198. Favuzzi E, et al. 2021. Cell. 184(15):4048-4063.e32. PubMed
  199. Szeifert V, et al. 2021. Front Immunol. 12:671995. PubMed
  200. Saber M, et al. 2021. J Neurosci Res. 99:1136. PubMed
  201. Wang W, et al. 2021. J Am Heart Assoc. 10:e019142. PubMed
  202. Berghoff SA, et al. 2021. Nat Neurosci. 24:47. PubMed
  203. Cao W, et al. 2021. Int J Mol Sci. 22:. PubMed
  204. Calle P, et al. 2021. Cells. 10:. PubMed
  205. Gladow N, et al. 2020. PLoS One. 15:e0227734. PubMed
  206. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  207. Li YT, et al. 2019. Elife. 8:e47642. PubMed
  208. Luck H, et al. 2019. Nat Commun. 10:3650. PubMed
  209. Xiao G, et al. 2018. Cell. 173:470. PubMed
  210. Spangenberg E, et al. 2019. Nat Commun. 10:3758. PubMed
  211. Wu ZJ, et al. 2018. Int J Oncol. 52:1209. PubMed
  212. Li T, et al. 2021. J Neuroinflammation. 81:18. PubMed
  213. Guo M, et al. 2020. Brain. 1476:143. PubMed
  214. Houben T, et al. 2020. J Pathol. 251:429. PubMed
  215. Cai Z, et al. 2020. Cell Rep. 31:107816. PubMed
  216. Li L, et al. 2014. J Immunol. 192:1034. PubMed
  217. Demers M, et al. 2012. Proc Natl Acad Sci U S A. 109:13076. PubMed
  218. Dong Y, et al. 2021. Commun Biol. 4:560. PubMed
  219. Scheiblich H, et al. 2021. Cell. 184:5089. PubMed
  220. Tomimatsu M, et al. 2022. Sci Rep. 12:16656. PubMed
  221. Bennett FC, et al. 2018. Neuron. 98:1170. PubMed
  222. Zhang T, et al. 2018. PLoS One. 13:e0196571. PubMed
  223. Eisemann T, et al. 2019. Front Oncol. 9:187. PubMed
  224. Cá B, et al. 2019. Front Microbiol. 1.876388889. PubMed
  225. Ding H, et al. 2016. Nat Commun. 7:11533. PubMed
  226. Yuan Y, et al. 2020. Front Physiol. 0.967361111. PubMed
  227. Varikuti S, et al. 2020. Br J Cancer. 122:1005. PubMed
  228. Toyohara T, et al. 2020. Cell Stem Cell. 27:147. PubMed
  229. Gerdes P, et al. 2022. Nat Commun. 13:7470. PubMed
  230. Düking T, et al. 2022. Sci Adv. 8:eabo7639. PubMed
  231. Wang X, et al. 2021. Cell. 184:5357. PubMed
  232. Li Y, et al. 2020. Theranostics. 10:2897. PubMed
  233. Xia D, et al. 2022. Mol Neurodegener. 17:41. PubMed
  234. Koide S, et al. 2022. iScience. 25:103603. PubMed
  235. Lin T, et al. 2021. PLoS Pathog. 17:e1009557. PubMed
  236. Casselli T, et al. 2021. PLoS Pathog. 17:e1009256. PubMed
  237. Muri J, et al. 2020. Cell Reports. 29(9):2731-2744.e4.. PubMed
  238. Liu Y, et al. 2019. Sci Rep. 9:18970. PubMed
  239. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  240. Yokomizo-Nakano T, et al. 2020. Cancer Res. 80:2523. PubMed
  241. Lin KH, et al. 2020. Nat Genet. 52:408. PubMed
  242. Jablonski K, et al. 2015. PLoS One. 10: 0145342. PubMed
  243. Sanders K, et al. 2015. Cancer Immunol Res. 3: 891-901. PubMed
  244. Yuan C, et al. 2015. Biochem Biophys Res Commun. 464: 249-255. PubMed
  245. Resende M, et al. 2013. J Immunol. 191:262. PubMed
  246. Rodríguez L, et al. 2021. Biomolecules. 11: . PubMed
  247. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  248. Zhang A, et al. 2021. Theranostics. 11:3839. PubMed
  249. Zhai T, et al. 2020. Clin Exp Pharmacol Physiol. 47:677. PubMed
  250. Yang N, et al. 2022. Nat Commun. 13:2336. PubMed
  251. Wang Z et al. 2019. Cell reports. 26(5):1273-1285 . PubMed
  252. Schaftenaar FH, et al. 2019. Sci Rep. 9:17391. PubMed
  253. Chao Y, et al. 2020. Sci Adv. 6:eaaz4204. PubMed
  254. Nguyen GT, et al. 2020. eLife. 9:e56656.. PubMed
  255. Hoyer FF, et al. 2020. Immunity. 51(5):899-914.e7.. PubMed
  256. Kuo P, et al. 2016. J Am Heart Assoc. 5: 002610. PubMed
  257. Li K, et al. 2020. Nat Commun. 4.844444444. PubMed
  258. Avalle L, et al. 2020. Mol Ther Methods Clin Dev. 0.793055556. PubMed
  259. Zhou Q, et al. 2020. Nat Immunol. 1.393055556. PubMed
  260. Bozoglu T, et al. 2022. Adv Sci (Weinh). 9:e2103867. PubMed
  261. Shen H, et al. 2022. Nat Commun. 13:5013. PubMed
  262. Zhang X, et al. 2022. J Exp Clin Cancer Res. 41:246. PubMed
  263. Zhou Y, et al. 2022. Theranostics. 12:5488. PubMed
  264. Sheng D, et al. 2022. J Immunother Cancer. 10:. PubMed
  265. Bahmani B, et al. 2021. Nat Commun. 12:1999. PubMed
  266. Fielding C, et al. 2022. Nat Commun. 13:543. PubMed
  267. Schmidt C, et al. 2005. J Immunol. 175:2286. PubMed
  268. Danne C et al. 2017. Cell host & microbe. 22(6):733-745 . PubMed
  269. Luo H, et al. 2019. Cell Rep. 26:945. PubMed
  270. Saber M, et al. 2020. Eur J Neurosci. 52:2791. PubMed
  271. Garcia-Bonilla L, et al. 2015. J Neurosci. 35: 14783 - 14793. PubMed
  272. Baruch K, et al. 2015. EMBO J. 34: 1816 - 1828. PubMed
  273. Wang K, et al. 2021. Nat Commun. 12:4558. PubMed
  274. Henkle TR, et al. 2021. Cancer Res. 81:4560. PubMed
  275. Gawish R, et al. 2022. Elife. 11:. PubMed
  276. Wang T, et al. 2022. Int J Nanomedicine. 17:2191. PubMed
  277. Wunderlich CM, et al. 2018. Nat Commun. 9:1646. PubMed
  278. Arima Y et al. 2017. eLife. 6 pii: e25517. PubMed
  279. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  280. Zhang M, et al. 2019. Autophagy. 1.423611111. PubMed
  281. Hirako N, et al. 2014. PLoS One. 9:103282. PubMed
  282. Chen Z, et al. 2016. Innate Immunity. 22: 419 - 432. PubMed
  283. Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
  284. Evavold CL, et al. 2021. Cell. 184(17):4495-4511.e19. PubMed
  285. Wu L, et al. 2020. Cancer Immunol Res. 710:8. PubMed
  286. Saber M, et al. 2021. J Neurotrauma. 38:2862. PubMed
  287. Sethuraman SN, et al. 2020. Theranostics. 10:3397. PubMed
  288. Zhang SJ, et al. 2021. Adv Sci (Weinh). 8:2003410. PubMed
  289. Steinmetz TD, et al. 2021. Autophagy. 17:2238. PubMed
  290. Hohsfield LA, et al. 2021. Elife. 10:. PubMed
  291. Kaya-Tilki E, et al. 2021. PLoS One. 16:e0260633. PubMed
  292. Zhang J, et al. 2021. Stem Cell Res Ther. 12:579. PubMed
  293. Amend A, et al. 2021. Int J Mol Sci. 22:. PubMed
  294. Rana MN, et al. 2021. Front Pharmacol. 12:643215. PubMed
  295. Cai W, et al. 2019. J Neuroinflammation. 0.788194444. PubMed
  296. Fernando N, et al. 2020. Front Cell Dev Biol. 0.691666667. PubMed
  297. Dougan M, et al. 2018. Cancer Immunol Res. 6:389. PubMed
  298. Abdel Malik R, et al. 2017. Circ Res. 120:99. PubMed
  299. Nabekura T, et al. 2020. Immunity. 96:52. PubMed
  300. Wong PP, et al. 2020. Cell. 181(6):1346-1363.e21. PubMed
  301. Guo S, et al. 2021. Frontiers in Immunology. 11:614667. PubMed
  302. Scharenberg SG, et al. 2020. Nat Commun. 2.76875. PubMed
  303. K K, et al. 2016. Haematologica. 151159. PubMed
  304. Han J, et al. 2015. Cancer Res . 75: 5273 - 5282. PubMed
RRID
AB_312790 (BioLegend Cat. No. 101207)
AB_312791 (BioLegend Cat. No. 101208)

Antigen Details

Structure
Integrin family, associates with integrin β2 (CD18), 170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells

Function
Adhesion, chemotaxis
Ligand/Receptor
ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Coxon A, et al. 1996. Immunity 5:653.

Gene ID
16409 View all products for this Gene ID 3684 View all products for this Gene ID
UniProt
View information about CD11b on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.

Other Formats

View All CD11b Reagents Request Custom Conjugation
Description Clone Applications
APC anti-mouse/human CD11b M1/70 FC
Biotin anti-mouse/human CD11b M1/70 FC
FITC anti-mouse/human CD11b M1/70 FC
PE anti-mouse/human CD11b M1/70 FC,IHC
PE/Cyanine5 anti-mouse/human CD11b M1/70 FC
Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,IHC-F,ICC
PE/Cyanine7 anti-mouse/human CD11b M1/70 FC
Alexa Fluor® 488 anti-mouse/human CD11b M1/70 FC,IHC-F,3D IHC,SB
Alexa Fluor® 647 anti-mouse/human CD11b M1/70 FC,3D IHC,SB
Alexa Fluor® 700 anti-mouse/human CD11b M1/70 FC
Pacific Blue™ anti-mouse/human CD11b M1/70 FC
APC/Cyanine7 anti-mouse/human CD11b M1/70 FC
PerCP/Cyanine5.5 anti-mouse/human CD11b M1/70 FC
PerCP anti-mouse/human CD11b M1/70 FC
Brilliant Violet 421™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 570™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 605™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 650™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 711™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 785™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 510™ anti-mouse/human CD11b M1/70 FC,ICC
Ultra-LEAF™ Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,Block,Depletion,IHC-F,ICC
Purified anti-mouse/human CD11b (Maxpar® Ready) M1/70 FC,CyTOF®
Alexa Fluor® 594 anti-mouse/human CD11b M1/70 IHC-F,FC
PE/Dazzle™ 594 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 750 anti-mouse/human CD11b M1/70 FC
TotalSeq™-A0014 anti-mouse/human CD11b M1/70 PG
Brilliant Violet 750™ anti-mouse/human CD11b M1/70 FC
TotalSeq™-B0014 anti-mouse/human CD11b M1/70 PG
TotalSeq™-C0014 anti-mouse/human CD11b M1/70 PG
Spark NIR™ 685 anti-mouse/human CD11b M1/70 FC
PE/Fire™ 640 anti-mouse/human CD11b M1/70 FC
Spark YG™ 593 anti-mouse/human CD11b M1/70 FC
Spark YG™ 570 anti-mouse/human CD11b M1/70 IHC-F
PE/Fire™ 810 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 810 anti-mouse/human CD11b Antibody M1/70 FC
Spark Blue™ 550 anti-mouse/human CD11b M1/70 FC
Spark UV™ 387 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 806 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 780 anti-mouse/human CD11b M1/70 FC
Spark Blue™ 574 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
KIRAVIA Blue 520™ anti-mouse/human CD11b M1/70 FC
Spark PLUS UV™ 395 anti-mouse/human CD11b M1/70 FC
Go To Top Version: 2    Revision Date: 03/14/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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