- αHUT7 (See other available formats)
- Regulatory Status
- Other Names
- T cell receptor Vbeta 23
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
Vβ23 T cell receptor (TCR Vβ23) is a variant of the TCR β chain which is heterodimerized with TCR α chain and expressed on a subset of αβ+ T cells. TCR α/β recognizes peptides presented by the MHC molecules and initiates T cell mediated immune responses.
Vβ23+ T cells are stimulated by the staphylococcal enterotoxin A (SEA) and by the pyrogenic toxin superantigens (PTSAgs) SpeK, SpeL, and SpeM from streptococcus.Product Details
- Antibody Type
- Host Species
- T-cell leukemia line HUT78
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: stimulation of HUT78 T cells to produce IL-21.
(PubMed link indicates BioLegend citation)
- Romagne F, et al. 1995. J. Immunol. Methods 186:313. (Stim)
- Rebai N, et al. 1994. P. Natl. Acad. Sci. USA 91:1529. (FC)
- Pantaleo G, et al. 1997. P. Natl. Acad. Sci. USA 94:9848. (FC)
AB_10918433 (BioLegend Cat. No. 349406)
- Immunoglobulin superfamily, associate with TCR Vα chain and CD3 complex
subset of TCR αβ+ T cells
- Recognition of peptides presented by MHC molecules, responsible for T cell mediated immune response
- MHC-peptide complex
- Cell Type
- T cells
- Biology Area
- Adaptive Immunity, Immunology
- Molecular Family
- Antigen References
1. Guilherme L, et al. 2007. Curr. Protein Pept. Sc. 8:39.
2. Adelman MK. 2007. Crit. Rev. Immunol. 27:221.
3. Beres SB, et al. 2002. P. Natl. Acad. Sci. USA 99:10078.
4. Smoot LM, et al. 2002. Infect. Immunol. 70:7095.
5. Lavoie PM, et al. 2005. Int. Immunol. 17:931.
- Gene ID
- 6957 View all products for this Gene ID
- View information about TCR V beta 23 on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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