- Clone
- 2.11 (See other available formats)
- Other Names
- T cell receptor Vgamma 1.1, TCR Vγ1, TCR Cr4
- Isotype
- Armenian hamster IgG
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
C57BL/6 mouse lymph node cells were stained with anti-mouse TCR γ/δ (clone GL3) APC and anti-mouse TCR Vγ1.1 (clone 2.11) FITC (top) or Armenian hamster IgG FITC isotype control (bottom). -
| Cat # | Size | Price | Save |
|---|---|---|---|
| 141103 | 25 µg | ¥19,000 | |
| 141104 | 100 µg | ¥39,000 |
T cell receptor (TCR) is a heterodimer consisting of an α and β chain (TCR α/β) or a γ and δ chain (TCR γ/δ). TCR associates with CD3 to form a CD3/TCR complex. The CD3/TCR plays a key role in antigen recognition, signal transduction, and T cell activation. TCR Vγ1.1 (Garman nomenclature) is also called TCR Vγ1 (Tonegawa nomenclature). The Vγ1 gene almost exclusively rearranges to the Jγ4-Cγ4 gene. Vγ1- Jγ4-Cγ4 expressing cells constitute a major population of γ/δ T cells in thymus and peripheral lymphoid organs in adult mice, but they are only composed of a minor population of γ/δ T cells during fetal and early postnatal life. Vγ1 T cell development can happen in thymus-dependent and thymus-independent manners. Further studies have shown that the antibody 2.11 recognized epitote is located in Cr4 domain.
Product DetailsProduct Details
- Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Armenian Hamster
- Immunogen
- T3.13.1 T-cell hybridoma cell line
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
- Application Notes
-
Additional reported applications (for the relevant formats) include: immunoprecipitation1.
-
Application References
(PubMed link indicates BioLegend citation) -
- Pereira P, et al. 1995. J. Exp. Med. 182:1921. (IP)
- Pereira P and Boucontet L. 2004. J. Immunol. 173:3261. (FC)
- Pereira P, et al. 1996. Intl. Immunol. 8:83. (FC)
- Product Citations
- RRID
-
AB_10694242 (BioLegend Cat. No. 141103)
AB_10697031 (BioLegend Cat. No. 141104)
Antigen Details
- Structure
- Ig superfamily
- Distribution
-
Subset of γ/δ T-cells
- Function
- Antigen recognition
- Ligand/Receptor
- Antigen
- Cell Type
- T cells
- Biology Area
- Immunology, Adaptive Immunity
- Molecular Family
- TCRs
- Antigen References
-
1. Pereira P, et al. 1995. J. Exp. Med. 182:1921.
2. Grigoriadou K, et al. 2002. J. Immunol. 169:3736. - Gene ID
- 110067 View all products for this Gene ID
- UniProt
- View information about TCR V gamma1.1 on UniProt.org
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