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- Clone
- W21075D (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Pref, protein delta homolog 1
- Isotype
- Rat IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Mouse NIH/3T3 fibroblast cells were stained with anti-mouse DLK1 (clone W21075D) APC (filled histogram) or rat IgG2b, κ APC isotype control (open histogram).
| Cat # | Size | Price | Save |
|---|---|---|---|
| 122303 | 25 µg | ¥37,840 | |
| 122304 | 100 µg | ¥82,280 |
The Delta-Notch pathway controls developmental processes including cell fate determination, terminal differentiation, and proliferation. In mammals, four Notch receptors (NOTCH1–4) and five activating canonical ligands (JAGGED1, JAGGED2, DLL1, DLL3 and DLL4) have been described. Delta-like 1 homolog (DLK1) is a noncanonical Notch ligand, and acts as an inhibitor of Notch signaling. The inhibitory effect of DLK1 and DLK2 on Notch signaling may be mediated by competition of with canonical ligands for the receptor binding site. Widely expressed during embryonic development, expression becomes restricted in the adult to (neuro)endocrine tissues like the pituitary gland, adrenal glands, pancreas, monoaminergic neurons in the central nervous system, testes, prostate, and ovaries.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- mDLK1-RBL1
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Red Laser (633 nm)
Antigen Details
- Structure
- Single-pass type I membrane protein
- Distribution
-
Cytoplasm, plasma membrane
- Function
- Neuroendocrine differentiation, inhibits adipocyte differentiation
- Interaction
- Notch receptors
- Ligand/Receptor
- Notch receptors
- Cell Type
- Fibroblasts, Neurons
- Biology Area
- Neuroscience, Signal Transduction
- Antigen References
-
- Smas C.M, et al. 1993. Cell. 73:725-34.
- Laborda J, et al. 1993. J Biol Chem. 268:3817-20.
- Montalban-Loro R, et al. 2021. Proc Natl Acad Sci USA. 118 (11).
- Zhang L, et al. 2021. Stem Cells. 39:306-17.
- Ichinose M, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 320:G506-20.
- Gene ID
- 13386 View all products for this Gene ID
- UniProt
- View information about DLK1 on UniProt.org
Related Pages & Pathways
Pathways
Related FAQs
Other Formats
View All DLK1 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| APC anti-mouse DLK1 | W21075D | FC |
| FITC anti-mouse DLK1 | W21075D | FC |
| PE anti-mouse DLK1 | W21075D | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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APC anti-mouse DLK1
Mouse NIH/3T3 fibroblast cells were stained with anti-mouse ... -
FITC anti-mouse DLK1
Mouse NIH/3T3 fibroblast cells were stained with anti-mouse ... -
PE anti-mouse DLK1
Mouse NIH/3T3 fibroblast cells were stained with anti-mouse ...
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