- A17193J (See other available formats)
- Regulatory Status
- Other Names
- CD6 ligand, Activated Leukocyte Cell Adhesion Molecule (ALCAM)
- Mouse IgG2b, κ
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- Product Citations
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CD166, also known as the CD6 ligand or the Activated Leukocyte Cell Adhesion Molecule (ALCAM), is a 100-105 kD transmembrane glycoprotein. It belongs to the Ig superfamily of proteins and expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, and neurons. CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development. Recently CD166 has also been used as a potential cancer stem cell marker. The antibody reacts with human activated leukocyte cell adhesion molecule (ALCAM).Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Recombinant human CD166
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
IHC-P - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_2814379 (BioLegend Cat. No. 397802)
- A type I transmembrane glycoprotein belonging to the Ig superfamily of proteins.
CD166 is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, and neurons.
- Play an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development.
- Cell Type
- B cells, Dendritic cells, Mesenchymal Stem Cells, Tregs
- Biology Area
- Cell Biology
- Molecular Family
- CD Molecules
- Antigen References
- Aruffo A, et al. 1997. Immunol Today. 18(10):498.
- Patel DD, et al. 1995. J. Exp. Med. 181:2213.
- Bowen MA, et al. 1995. J. Exp. Med. 181:1563.
- Horst D, et al. 2009. Cancer Invest. 8:844-50.
- Gene ID
- 214 View all products for this Gene ID
- View information about CD166 on UniProt.org
|Purified anti-human CD166||A17193J||IHC-P|
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