- A2F10 (See other available formats)
- Regulatory Status
- Other Names
- Flk-2, Flt3, Ly-72
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
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CD135, also known as Flk-2, Flt3, and Ly-72, is a type III tyrosine kinase receptor. It is expressed on early B lymphoid lineage cells in bone marrow, on primitive myeloid progenitors within the BM CD34+ cell population. Ligation of Flk-2 with Flt3 ligand regulates the growth of hematopoietic stem cells and promotes the survival of primitive hematopoietic progenitor cells with myeloid as well as B lymphoid potential. It was reported that the receptor tyrosine kinase Flt3 is required for dendritic cell development. Combined signaling through interleukin-7 receptors and Flt3 selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells.Product Details
- Antibody Type
- Host Species
- Mouse Flt3 transfected cell line
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
- Sergejeva S, et al. 2004. Blood 103:1270.
- Auffray C, et al. 2009. J. Exp. Med. 206:595.
- Chiba H, et al. 2013. Am J Physiol Cell Physiol. 305:693. PubMed
- Product Citations
AB_1953266 (BioLegend Cat. No. 135307)
AB_1953267 (BioLegend Cat. No. 135308)
- A 135-150 kD molecule belonging to the tyrosine kinase receptor family.
Expressed on early B lymphoid lineage cells in juvenile and adult bone marrow, primitive myeloid progenitors within the BM CD34+ cell population.
- Regulate the growth of hematopoietic stem cells and promote the survival of primitive hematopoietic progenitor cells.
- Flk-2/FLT3 ligand
- Cell Type
- B cells, Hematopoietic stem and progenitors
- Biology Area
- Molecular Family
- CD Molecules
- Antigen References
1. Waskow C, et al.Nat. Immunol. 9:676
2. Veiby OP, et al. 1996. Blood 88(4):1256
3. Veiby OP, et al. 1996. J. Immunol. 157(7):2953
4. Mattews W, et al. 1991. Cell. 65(7):1143
5. Hannum C, et al. 1994. Nature 368(2):643
6. Ogawa M, et al. 1998. Exp Hematol. 26(6):478
- Gene ID
- 14255 View all products for this Gene ID
- View information about CD135 on UniProt.org
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
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