- QA17A19 (See other available formats)
- Regulatory Status
- Other Names
- Leukocyte Common Antigen, LCA, T200
- Mouse IgG1, κ
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- Product Citations
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CD45 is a 180 - 240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes or platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Red Laser (633 nm)
- Application Notes
Clone QA17A19 does not block clones 2D1 and HI30 indicating a unique epitope.
AB_2750082 (BioLegend Cat. No. 393405)
AB_2750083 (BioLegend Cat. No. 393406)
- Type I transmembrane protein, 180 - 240 kD (multiple isoforms)
Hematopoietic cells, except circulating erythrocytes or platelets.
- Tyrosine phosphatases, signaling, co-stimulation (co-inhibition), TCR and BCR mediated activation.
- Galectin-1, CD2, CD3, and CD4.
- Cell Type
- B cells, Dendritic cells, Neutrophils
- Biology Area
- Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Inhibitory Molecules
- Molecular Family
- CD Molecules, TCRs
- Antigen References
- Thomas M. 1989. Annu. Rev. Immunol. 7:339.
- Trowbridge I, Thomas ML. 1994. Annu. Rev. Immunol. 12:85.
- Gene ID
- 5788 View all products for this Gene ID
- View information about CD45 on UniProt.org
Related Pages & Pathways
Other FormatsView All CD45 Reagents Request Custom Conjugation
|Purified anti-human CD45 Recombinant Antibody||QA17A19||FC|
|Alexa Fluor® 488 anti-human CD45 Recombinant Antibody||QA17A19||FC|
|Alexa Fluor® 647 anti-human CD45 Recombinant Antibody||QA17A19||FC|
|PerCP/Cyanine5.5 anti-human CD45 Recombinant Antibody||QA17A19||FC|
|PE/Cyanine7 anti-human CD45 Recombinant Antibody||QA17A19||FC|
|PE anti-human CD45 Recombinant Antibody||QA17A19||FC|
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