- SP12 (See other available formats)
- Regulatory Status
- Other Names
- Synaptosomal-associated protein 25, SUP, RIC-4, RIC4, SEC9, SNAP
Covance Catalog# MMS-614P
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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SNAP-25, also known as synaptosomal-associated protein 25, is a component of the trans-SNARE complex. It is a Q-SNARE protein anchored to the membrane on the cytosolic face, and does not contain a trans-membrane domain. The SNARE complex is involved in the vesicle fusion process. SNAP-25 is implicated in the inhibition of voltage-gated calcium channels, and has been shown to decrease calcium responsiveness in glutamatergic synapses.Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Host Species
- This antibody was raised against a crude synaptic preparation from the post mortem human brain.
- Phosphate-buffered solution (no preservatives or carrier proteins).
- The antibody was purified by affinity chromatography.
- 1 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
IHC-P - Quality tested
WB - Verified
IP - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10 µg/mL is suggested. For Western blotting, the suggested use of this reagent is 0.2 - 2.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Honer WG, et al. 1993. Brain Res. 609:9-20.
- Brinkmalm A, et al. 2014. Mol. Neurodegener. 9:53. (IP) PubMed
- Product Citations
AB_2728531 (BioLegend Cat. No. 805002)
AB_2564674 (BioLegend Cat. No. 805001)
|Purified anti-SNAP-25||SP12||IHC-P, WB, IP|
|HRP anti-SNAP-25||SP12||WB, IHC-P|
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