Purified anti-mouse NK-1.1 Recombinant Antibody

Pricing & Availability
Clone
QA19A51 (See other available formats)
Regulatory Status
RUO
Other Names
NKR-P1C, NKR-P1B, Ly-55, CD161, CD161b, CD161c
Isotype
Rat IgG2a, κ
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Product Citations
publications
QA19A51_PURE_NK1dot1_Recombinant_Antibody_v2_052121.png
C57BL/6 mouse splenocytes were stained with CD49b (DX5) APC and purified NK1.1 recombinant (clone QA19A51) (left) or purified rat IgG2a, κ isotype control (right), followed by anti-rat IgG2a PE.
  • QA19A51_PURE_NK1dot1_Recombinant_Antibody_v2_052121.png
    C57BL/6 mouse splenocytes were stained with CD49b (DX5) APC and purified NK1.1 recombinant (clone QA19A51) (left) or purified rat IgG2a, κ isotype control (right), followed by anti-rat IgG2a PE.
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161902 100 µg 48€
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Description

NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Recombinant
Host Species
Rat
Immunogen
NK-1+ cells from mouse spleen and bone marrow
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2892331 (BioLegend Cat. No. 161902)

Antigen Details

Structure
NKR-P1 gene family
Distribution

NK and NK-T cells in the NK1.1 mouse strains (C57BL, FVB/N, NZB)

Function
NK cell activation, IFN-γ production, cytotoxic granule release
Interaction
NK cells, NKT cells
Cell Type
NK cells, NKT cells
Biology Area
Immunology, Innate Immunity
Antigen References
  1. Lanier LL. 1997. Immunity. 6:371.
  2. Yokoyama WM, et al. 1993. Ann Rev Immunol. 11:613.
  3. Koo GC, et al. 1986. J Immunol. 137:3742.
  4. Giorda R, et al. 1991. J Immunol. 147:1701.
Gene ID
17059 View all products for this Gene ID
UniProt
View information about NK-1.1 on UniProt.org
Go To Top Version: 1    Revision Date: 05/21/2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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