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Purified anti-mouse DLL3 Antibody

Pricing & Availability
Clone
RMD3-13 (See other available formats)
Regulatory Status
RUO
Other Names
Delta like 3, M-Delta-3, delta3, drosophila Delta homolog 3
Isotype
Rat IgG2b, κ
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Product Citations
publications
RMD3-13_PURE_DLL3_Antibody_010218
OP9-DLL3 transfected cells were fixed, permeabilized, and intracellularly stained with purified DLL3 (clone RMD3-13, solid histogram) or purified rat IgG2b, κ isotype control (open histogram), followed by anti-rat IgG PE secondary.
  • RMD3-13_PURE_DLL3_Antibody_010218
    OP9-DLL3 transfected cells were fixed, permeabilized, and intracellularly stained with purified DLL3 (clone RMD3-13, solid histogram) or purified rat IgG2b, κ isotype control (open histogram), followed by anti-rat IgG PE secondary.
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154002 500 µg 315€
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Description

Delta like canonical Notch ligand 3 (DLL3) is consist of a DSL domain, EGF  repeats and transmembrane region. Inhibits Notch 1 in its cis format. Involved in embryonic development processes such as T cells development, specifying neuron's fate during neurogenesis and maintaining tissue homeostasis in adults. Potential target for preventing growth of cancer cells in small cell lung cancer.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse DLL3-FC
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.06 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Staining for DLL3 using clone RMD3-13 requires fixation and permeabilization. This clone does not work for surface DLL3 staining.

Application References

(PubMed link indicates BioLegend citation)
  1. Murata A, et al. 2014. PLoS One. 9:e108535.
RRID
AB_2728210 (BioLegend Cat. No. 154002)

Antigen Details

Structure
Type I transmembrane protein with a DSL domain and 6 or 8 EGF-like repeats
Distribution

Thymus, Brain

Function
Embryogenesis, maintaining tissue homeostasis
Interaction
Inhibition of Notch downstream signaling
Ligand/Receptor
Notch 1
Antigen References

1. Deng S M, et al. 2017. Biochem Biophys Res Commun. 483:488.
2. Shapiro F. 2016. Adv. Anat. Embryol. Cell. Biol. 221:67.
3. Saunders LR, et al. 2015. Sci Transl Med. 7:302.
4. Dvoriantchikova G, et al. 2015. PLoS One. 10:e0131054. 

Gene ID
13389 View all products for this Gene ID
UniProt
View information about DLL3 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 04/30/2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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