- W21047I (See other available formats)
- Regulatory Status
- Other Names
- Arginase 1, liver type Arginase, Type I Arginase, ARG1
- Rat IgG2b, κ
- Ave. Rating
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- Product Citations
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ARG1 (Arginase 1), is a marker for the M2 anti-inflammatory macrophage subset that hydrolyzes l-arginine into urea and ornithine, and plays an important role in wound healing, antiviral immune responses, and atherosclerosis. The inherited deficiency of this enzyme results in argininemia, which is an autosomal recessive disorder characterized by hyperammonemia. Recent studies show that intracellular pathogens induce the expression of ARG1 in mouse macrophages through the Toll-like receptor (TLR) pathway. The deletion of this enzyme in macrophages favors host survival. Other studies indicate that ARG1 also plays a role in T cell responses and selective antagonists of ARG1 might prove beneficial in fighting diseases in which T-cell responses are inappropriately suppressed.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- E. coli expressed protein aa 1-323
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone W21047I does not block the staining of reference clone A1eXF5 on the target cells (BMDM).
AB_3068107 (BioLegend Cat. No. 165802)
- 322 amino acids with a predicted molecular weight of approximately 35 kD
Express on dendritic cells & macrophages. Expressed predominantly in the liver. It can also be induced in macrophages. It is cytoplasmic target.
- Arginase 1 plays an important role in processes such as wound healing, antiviral immune response, and atherosclerosis.
- Binds 2 manganese ions per subunit as a cofactor
- Cell Type
- Biology Area
- Cell Biology, Immunology, Neuroinflammation, Neuroscience
- Molecular Family
- Enzymes and Regulators
- Antigen References
- Wu G, et al. 1998. Biochem J. 336:1.
- El Kasmi KC, et al. 2008. Nat Immunol. 9:1399-406.
- Pesce JT, et al. 2009. PLoS Pathog. 5:e1000371.
- Burrack KS, et al. 2014. Front Immunol. 5:428.
- Pourcet B, et al. 2013. Trends Cardiovasc Med. 23:143-52.
- Bronte V, et al. 2003. Trends Immunol. 24:302-6.
- Gene ID
- 383 View all products for this Gene ID
- View information about Arginase 1 on UniProt.org
|Purified anti-mouse Arginase 1||W21047I||ICFC|
|PE anti-mouse Arginase 1||W21047I||ICFC|
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