Purified anti-human BDNF Antibody

Pricing & Availability
A15062G (See other available formats)
Regulatory Status
Other Names
Brain-derived neurotrophic factor, ANON2, BLUN2
Mouse IgG1, κ
Ave. Rating
Submit a Review
Product Citations
Cat # Size Price Quantity Check Availability Save
536702 500 µg 436€
Check Availability

Need larger quantities of this item?
Request Bulk Quote

Brain-derived neurotrophic factor (BDNF) is the second member of the NGF family of neurotrophic factors (neurotrophins), which includes nerve growth factor (NGF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5). BDNF shares approximately 55% amino acid identity with other family members. The amino acid sequence of mature BDNF is identical in all mammalian species examined to date. Mature BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems during development. BDNF participates in axonal growth, pathfinding, and in the modulation of dendritic growth and morphology. BDNF is also a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the central nervous system (CNS). High levels of expression of BDNF have been detected in the hippocampus, cerebellum, fetal eye, and placenta. BDNF binds with high affinity and specifically activates the TrkB tyrosine kinase receptor. BDNF is also associated with multiple diseases such as Schizophrenia, Rett syndrome, obsessive compulsive disorder, Huntington’s disease, eating disorders, depression, dementia and Alzheimer’s disease. For example, BDNF levels are decreased in the serum of Alzheimer’s disease patients.

Product Details
Technical Data Sheet (pdf)

Product Details

Antibody Type
Host Species
Recombinant protein
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

ELISA Capture - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by ELISA assay. For ELISA Capture applications, a concentration range of 1 - 4 µg/mL is recommended. To obtain a linear standard curve, serial dilutions of BDNF recombinant protein ranging from 156.3 to 10,000 pg/mL is recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

The purified A15062G antibody is useful as the capture antibody in a sandwich ELISA assay, when used in conjunction with the biotinylated A15062F antibody (Cat. No. 536804) as the detection antibody and Recombinant Human BDNF (ELISA Std.) (Cat. No. 759709).

Although not tested, additional species reactivity for rat, donkey, equine, porcine, and monkey are predicted based on 100% amino acid sequence conservation for this target across listed species.

AB_2783342 (BioLegend Cat. No. 536702)

Antigen Details

Noncovalently linked homodimer.

Ubiquitous with high levels in peripheral tissues including prostate, placenta, pancreas, heart, kidney, pituitary gland, lung, and testis.

Supports the survival of sensory and sympathetic neurons, and also dopaminergic midbrain neurons.
Sensory neurons, sympathetic neurons, midbrain dopaminergic neurons
Antigen References
  1. Baloh RH, et al. 1998. Neuron. 21:1291.
  2. Masure S, et al. 1999. Eur. J. Biochem. 266:892-902.
  3. Gardell LR, et al. 2003. Nat. Med. 9(11):1383-9.
  4. Honma Y, et al. 2002. Neuron. 35:267-82.
  5. Banerjee A, et al. 2012. PLoS One 7(11):e50098.
  6. Wong LE, et al. 2015. Proc. Natl. Acad. Sci. USA 112:6170-5.
  7. Zhang M, et al. 2016. Oncotarget. 7:3267-82.
Gene ID
627 View all products for this Gene ID
View information about BDNF on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 06/14/2022

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


BioLegend Inc., 8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Purified anti-human BDNF


Login / Register
Remember me
Forgot your password? Reset password?
Create an Account