- HP-3G10 (See other available formats)
- Regulatory Status
- Other Names
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD161 is a type II transmembrane glycoprotein, also known as NKR-P1A, that is expressed as a 40-44 kD homodimer. It is a member of the C-type lectin superfamily. CD161 is expressed on a majority of NK cells, NKT cells, and subsets of peripheral T cells and CD3+ thymocytes. It has been reported that Th17 cells are a subpopulation of CD4+CD161+CCR6+ cells. While the biological function of CD161 is not clear, it has been suggested to serve either as a stimulatory receptor or to inhibit NK cell-mediated cytotoxicity and cytokine production. LLT-1 (lectin-like transcript-1, also named as osteoclast inhibitory lectin or CLEC2D) is the ligand of CD161.Product Details
- Verified Reactivity
- Human, Cynomolgus, Rhesus
- Reported Reactivity
- African Green, Baboon
- Antibody Type
- Host Species
- Human NK cells
µg size: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
test sizes: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
- The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
- µg sizes: 0.5 mg/mLtest sizes: lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining using the µg size, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application. For flow cytometric staining using the test sizes, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: inhibition of cytokine production and Western blotting under nonreducing conditions.
(PubMed link indicates BioLegend citation)
- Gumß M, et al. 2004. Blood 104:3664.
- Exley M, et al. 1998. J. Exp. Med. 188:867.
- Marquez C, et al. 1998. Blood 91:2760.
- Product Citations
AB_1574986 (BioLegend Cat. No. 339905)
AB_2564140 (BioLegend Cat. No. 339936)
AB_2234362 (BioLegend Cat. No. 339906)
- Type II glycoprotein, 40-44 kD homodimer, C-type lectin superfamily
NK cells, T subset, subset of CD3+ thymocytes
- LLT-1 (Lectin-like transcript-1)
- Cell Type
- NK cells, T cells, Thymocytes
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Molecular Family
- CD Molecules
- Antigen References
1. Takahashi T, et al. 2006. J. Immunol. 176:211.
2. Cosmi L, et al. 2008. J. Exp. Med. 205:1903.
3. Aldemir H, et al. 2005. J. Immunol. 175:7791.
4. Rosen DB, et al. 2008. J. Immunol. 180:6508.
- Gene ID
- 3820 View all products for this Gene ID
- View information about CD161 on UniProt.org
Related Pages & Pathways
Other FormatsView All CD161 Reagents Request Custom Conjugation
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Brilliant Violet 510™ anti-human CD161
FITC anti-human CD161
Purified anti-human CD161
PE anti-human CD161
PerCP/Cyanine5.5 anti-human CD161
Alexa Fluor® 647 anti-human CD161
APC anti-human CD161
Brilliant Violet 421™ anti-human CD161
Brilliant Violet 605™ anti-human CD161
PE/Cyanine7 anti-human CD161
Alexa Fluor® 700 anti-human CD161
Purified anti-human CD161 (Maxpar® Ready)
Alexa Fluor® 488 anti-human CD161
Pacific Blue™ anti-human CD161
APC/Cyanine7 anti-human CD161
Brilliant Violet 785™ anti-human CD161
Biotin anti-human CD161
PerCP anti-human CD161
PE/Dazzle™ 594 anti-human CD161
APC/Fire™ 750 anti-human CD161
TotalSeq™-A0149 anti-human CD161
TotalSeq™-C0149 anti-human CD161
TotalSeq™-B0149 anti-human CD161
PE/Cyanine5 anti-human CD161 Antibody
TotalSeq™-D0149 anti-human CD161
Spark Red™ 718 anti-human CD161