- 16B5C71 (See other available formats)
- Other Names
- IK1, IKZF1
- Mouse IgG2a, κ
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- Product Citations
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Ikaros, also known as IKZF1, belongs to a family of zinc-finger DNA-binding proteins that regulate lymphocyte differentiation. It has the ability to form homo- and heterodimers with other members of the Ikaros family, which include Aiolos and Helios. Ikaros can be found on a majority of fetal and adult hematopoietic cell types such as T- and B-cells, natural killer cells (NKs), monocytes/macrophages, and dendritic cells. Ikaros is a tumor suppressor and its absence or reduced expression has been reported in several leukemias.Product Details
- Antibody Type
- Host Species
- Human Ikaros peptide (431-477 aa) conjugated to KLH Freund's adjuvant.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
ChIP - Quality tested
WB - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by ChIP assay. The recommended starting antibody to chromatin ratio is 4 µg of antibody and 5 µg of chromatin per IP. Optimal antibody to chromatin ratio should be determined by the end user. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per mL. It is recommended that the reagent to be titrated for optimal performance before each experiment.
- Application Notes
There are eight splicing variants with predicted MW 58, 53, 48(2), 43, 41, 31, 24 KDa. This antibody might recognize some of the isoforms.
AB_2721587 (BioLegend Cat. No. 687103)
AB_2721588 (BioLegend Cat. No. 687104)
- Zinc-finger DNA binding protein, homo/heterodimer, 57.5 kD
Fetal and adult hematopoietic cells.
- Regulates lymphocyte differentiation.
- Cell Type
- B cells, Dendritic cells
- Biology Area
- Cell Biology, Chromatin Remodeling/Epigenetics, Immunology, Signal Transduction, Transcription Factors
- Molecular Family
- Nuclear Markers
- Antigen References
1. Wargnier A, et al. 1995. Proc. Natl. Acad. Sci. USA 92:6930.
2. Tonnelle C, et al. 2009. Mol. Immunol. 46:1736.
3. Wang H, et al. 2014. Pediatr. Blood Cancer 61:2230.
- Gene ID
- 10320 View all products for this Gene ID
- View information about Ikaros on UniProt.org
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