Purified anti-mouse CD51 Antibody

Pricing & Availability
Clone
HMαV-1 (See other available formats)
Regulatory Status
RUO
Other Names
αv integrin, Vitronectin Receptor, Integrin αv chain, ITGAV
Isotype
Armenian Hamster IgG
Ave. Rating
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Product Citations
publications
HMalphaV-1_PURE_Integrin_Alpha_V_Antibody_1_060917
C57BL/6 mouse bone marrow cells were stained with CD51 (clone HMαV-1) (filled histogram) or Armenian Hamster IgG isotype control (open histogram), followed by goat-anti-hamster (Armenian) IgG FITC.
  • HMalphaV-1_PURE_Integrin_Alpha_V_Antibody_1_060917
    C57BL/6 mouse bone marrow cells were stained with CD51 (clone HMαV-1) (filled histogram) or Armenian Hamster IgG isotype control (open histogram), followed by goat-anti-hamster (Armenian) IgG FITC.
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153202 500 µg 184€
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Description

CD51 is a 140 kD protein, also known as αV integrin, vitronectin receptor, and integrin αV. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins β1, β3, β5 or β6; these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The αv integrin heterodimers have varied functions in development, stimulation/activation and homeostasis. The primary ligands for CD51 complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Affinity-purified αVβ3
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.1 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2687270 (BioLegend Cat. No. 153202)

Antigen Details

Structure
Integrin family, associates with integrins β1, β3, β5 or β6, 140 kD
Distribution

Activated T cells, polymorphonuclear granulocytes, blastocysts, osteoclasts

Function
Adhesion
Ligand/Receptor
Fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31.
Cell Type
T cells, Granulocytes, Osteoclasts
Biology Area
Cell Adhesion, Cell Biology, Immunology, Costimulatory Molecules
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Maxfield SR, et al. 1989. J. Exp. Med. 169:2173.
2. Piali L, et al. 1995. J. Cell Biol. 130:451.

Gene ID
16410 View all products for this Gene ID
UniProt
View information about CD51 on UniProt.org
Go To Top Version: 0    Revision Date: 06/12/2017

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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