- A15032A (See other available formats)
- Regulatory Status
- Other Names
- Interleukin 1, alpha, IL-1A, IL1F1
- Mouse IgG2a, κ
- Ave. Rating
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- Product Citations
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IL-1 (Interleukin-1) is a central mediator of innate immunity and inflammation. The IL-1 family includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ), three receptor antagonists (IL-1RA, IL-36RA, IL-38), and an anti-inflammatory cytokine (IL-37). A tight regulation through receptor antagonists, decoy receptors, and signaling inhibitors ensures a balance between amplification of innate immunity and uncontrolled inflammation. The cytokine IL-1α is a key molecule in the IL-1 family that induces autonomous proliferation in vascular smooth muscle cells, T cell activation during antigen presentation, up-regulation of monocyte/macrophage-mediated tumor cytotoxicity, stimulation of osteoclast formation, and production of proteinases in human chondrocytes. Furthermore, IL-1α is also an early and important mediator of inflammation after injury.Product Details
- Antibody Type
- Host Species
- Human IL-1α, amino acids Ser113-Ala271 (Accession# NM_000575) was expressed in E. coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
ICC - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg/ml. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone A15032A weakly reacts with mouse IL-1a.
AB_2616884 (BioLegend Cat. No. 686502)
- 271 amino acids with the predicted molecular weight of approximately 31kD.
IL-1α is produced by monocytes, macrophages, keratinocytes, stimulated B lymphocytes, fibroblasts, endothelial cells, and epithelial cells.
- The cytokine IL-1α is a key molecule both in the innate and in the adaptive immune response. It induces autonomous proliferation in vascular smooth muscle cells, T cell activation during antigen presentation, up-regulation of monocyte/macrophage-mediated tumor cytotoxicity, stimulation of osteoclast formation, and production of proteinases in human chondrocytes.
- Stimulates thymocyte and B-cell proliferation.
- Type I and II IL-1 receptors (IL-1RA and IL-1RB).
- Cell Type
- B cells, Neutrophils
- Biology Area
- Angiogenesis, Cancer Biomarkers, Cell Biology, Cell Cycle/DNA Replication, Cell Motility/Cytoskeleton/Structure, Cell Proliferation and Viability, Immunology, Innate Immunity, Signal Transduction
- Molecular Family
- Antigen References
1. Ledford H. 2007. Nature 450:600.
2. Boraschi D, Tagliabue, A. 2006. Vitam. Horm. 74:229.
3. Shao J, Sheng H. 2007. J. Immunol. 178:4097.
4. Elaraj DM, et al. 2006. Clin. Cancer Res. 12:1088.
5. Schett G, et al. 2016. Nat. Rev. Rheumatol. 12:14.
6. Brough D, et al. 2015. IUBMB Life 67:323.
7. Dinarello CA, et al. 2014. Mol. Med. 20 Suppl. 1:S43-58.
8. Voronov E, et al. 2014. Front Physiol. 5:114.
9. Garlanda C, et al. 2013. Immunity 39:1003.
10. Rider P, et al. 2013. Semin. Immunol. 25:430.
- Gene ID
- 3552 View all products for this Gene ID
- View information about IL-1alpha on UniProt.org
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