- Syn514 (See other available formats)
- Regulatory Status
- Other Names
- Synuclein alpha-140, non-A4 component of amyloid, alpha-synuclein, isoform NACP140, non-A beta component of AD amyloid Parkinson disease (autosomal dominant, Lewy body) 4
- Mouse IgG1, κ
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- Product Citations
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Synucleins are small soluble proteins expressed primarily in neural tissues and in certain tumors. The family includes 3 known proteins: alpha-, beta-, and gamma-synuclein. All synucleins have in common a highly conserved alpha helical lipid binding motif with similarity to the class-A2 lipid binding domains of the exchangeable apolipoproteins. The alpha- and beta-synuclein proteins are found primarily in brain tissue, where they are seen mainly in the pre-synaptic terminals. Alpha-synuclein is believed to be a major component of Lewy bodies in Parkinson's disease. Mutations in alpha-synuclein are associated with rare familial cases of early onset Parkinson's disease (PD), Alzheimer's disease (AD) and several other neurodegenerative illnesses. Oxidative injury has been implicated in the pathogenesis of neurodegenerative disorders including AD and PD.Product Details
- Antibody Type
- Host Species
- Syn514 was raised using oxidized alpha-synuclein (α-synuclein) and recognizes its native and nitrated/oxidized forms.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
IHC-P - Quality tested
ICC - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 0.5 - 5.0 µg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: immunofluorescent staining3,7.
Syn514 also shows some cross reactivity with beta- and gamma-synuclein.
- Application References
- Duda JE, et al. 2002. Ann. Neurol. 52(2):205-10.
- Giasson BI, et al. 2000. Science 290:985.
- Waxman EA, Giasson BI. 2008. J. Neuropathol. Exp. Neurol. 5:402. (IF)
- Daher JP, et al. 2014. Proc. Natl. Acad. Sci. USA 25:9289. (IHC)
- Uryu K, et al. 2003. Exp. Neurol. 1:214. (IHC)
- Auluck PK, et al. 2002. Science 5556:865. (IHC)
- Mazzulli JR, et al. 2007. J. Biol. Chem. 43:31621. (IF)
- Product Citations
AB_2616740 (BioLegend Cat. No. 838903)
- Alpha synuclein is 140 amino acids and has a molecular mass of 14 kD.
Cytoplasm, nucleus, and extracellular.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- Gene ID
- 6622 View all products for this Gene ID
- View information about Synuclein-alpha, Nitrated on UniProt.org
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