- 13A3-1 (See other available formats)
- Regulatory Status
- Other Names
- Signal transducer and activator of transcription 3, Acute-phase response factor, APRF, HIES
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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Tyrosine phosphorylation of STAT3 at Tyr705 occurs in response to LIF, IL-6, leptin, OSM, EGF, PDGF, and HGF. It plays a key role in cell growth and apoptosis through mediating expression of a variety of genes in response to the stimuli.Product Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Host Species
- KLH conjugated modified synthetic peptide
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with PerCP/Cyanine5.5 under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular flow cytometry using our True-Phos™ Perm Buffer in Whole Blood Protocol. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* PerCP/Cyanine5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.
- Excitation Laser
Blue Laser (488 nm)
- Application Notes
The STAT3 Phospho (Tyr705) antibody recognizes the regulatory tyrosine phosphorylation of human STAT3 protein and has been shown to be useful for Western blotting.
- Additional Product Notes
- BioLegend is in the process of converting the name PerCP/Cy5.5 to PerCP/Cyanine5.5. The dye molecule remains the same, so you should expect the same quality and performance from our PerCP/Cyanine5.5 products. Contact Technical Service if you have any questions.
- Product Citations
AB_2728485 (BioLegend Cat. No. 651021)
AB_2728486 (BioLegend Cat. No. 651022)
- STAT3 is a 770 amino acid protein of 88 kD. It consists of a DNA binding domain, a SH2 domain, a regulatory tyrosine responsible for binding of SH2 domain, and a C-terminal transactivation domain.
- STAT3 is tyrosine phosphorylated by receptor kinases in response to a variety of cytokines and growth factors. It forms homo- or heterodimer with STAT1 when tyrosine is phosphorylated, and then translocates to nucleus, acting as a transcription regulator. It is also essential for the differentiation of TH17 cells, which is involved in autoimmune diseases.
- Cell Sources
- Cytoplasm. Translocate to nucleus in response to tyrosine phosphorylation.
- Cell Type
- Embryonic Stem Cells, Neural Stem Cells
- Biology Area
- Cell Biology, Neuroscience, Neuroscience Cell Markers, Signal Transduction, Stem Cells, Synaptic Biology, Transcription Factors
- Molecular Family
- Antigen References
1. Akira S, et al. 1994. Cell 77:63.
2. Zhang X, et al. 1995. Science 267:1990.
3. Sanchez-Margalet V, et al. 2001. Cell. Immunol. 211:30.
4. Simon A, et al. 2000. Science 290:144.
5. Hoey T, et al. 1999. Adv. Immunol. 71:145.
- The small GTPase Rac1 binds and regulates activity of STAT3.
- Gene ID
- 6774 View all products for this Gene ID
- View information about STAT3 Phospho Tyr705 on UniProt.org
- How stable is PerCP/Cyanine5.5 tandem as compared to PerCP alone?
PerCP/Cyanine5.5 is quite photostable and also better than PerCP alone in withstanding fixation.
|Purified anti-STAT3 Phospho (Tyr705)||13A3-1||WB, ICC, ChIP|
|PE anti-STAT3 Phospho (Tyr705)||13A3-1||ICFC|
|Alexa Fluor® 488 anti-STAT3 Phospho (Tyr705)||13A3-1||ICFC|
|Brilliant Violet 421™ anti-STAT3 Phospho (Tyr705)||13A3-1||ICFC|
|Alexa Fluor® 647 anti-STAT3 Phospho (Tyr705)||13A3-1||ICFC|
|Direct-Blot™ HRP anti-STAT3 Phospho (Tyr705)||13A3-1||WB|
|PE/Cyanine5 anti-STAT3 Phospho (Tyr705)||13A3-1||ICFC|
|FITC anti-STAT3 Phospho (Tyr705)||13A3-1||ICFC|
|PerCP/Cyanine5.5 anti-STAT3 Phospho (Tyr705)||13A3-1||ICFC|
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-STAT3 Phospho (Tyr705)
PE anti-STAT3 Phospho (Tyr705)
Alexa Fluor® 488 anti-STAT3 Phospho (Tyr705)
Brilliant Violet 421™ anti-STAT3 Phospho (Tyr705)
Alexa Fluor® 647 anti-STAT3 Phospho (Tyr705)
Direct-Blot™ HRP anti-STAT3 Phospho (Tyr705)
PE/Cyanine5 anti-STAT3 Phospho (Tyr705)
FITC anti-STAT3 Phospho (Tyr705)
PerCP/Cyanine5.5 anti-STAT3 Phospho (Tyr705)