Purified anti-TTF-1 Antibody (Previously Covance catalog# SIG-3830)

Pricing & Availability
Clone
8G7G3/1 (See other available formats)
Regulatory Status
RUO
Other Names
Thyroid Transcription Factor, Homeobox protein Nkx-2.1, thyroid nuclear factor 1, thyroid transcription factor 1 TTF-1 NK-2
Previously
Signet Catalog# 830-26 L2 Predilute
Covance Catalog# SIG-3830
Isotype
Mouse IgG1
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Product Citations
publications
8G7G3-1_PURE_TTF-1_Antibody_1_120619
IHC staining of purified anti-TTF-1 antibody (clone 8G7G3/1) on formalin-fixed paraffin-embedded human lung tumor tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with the primary antibody for 60 minutes at room temperature. BioLegend´s Ultra-Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective. Scale bar: 50 µm
  • 8G7G3-1_PURE_TTF-1_Antibody_1_120619
    IHC staining of purified anti-TTF-1 antibody (clone 8G7G3/1) on formalin-fixed paraffin-embedded human lung tumor tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with the primary antibody for 60 minutes at room temperature. BioLegend´s Ultra-Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective. Scale bar: 50 µm
  • 8G7G3-1_PURE_TTF-1_Antibody_2_120619
    IHC staining of purified anti-TTF-1 antibody (clone 8G7G3/1) on formalin-fixed paraffin-embedded rat lung tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with the primary antibody for 60 minutes at room temperature. BioLegend´s Ultra-Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective. Scale bar: 50 µm
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918101 6 mL 209,00€
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Description

Transcription termination factor-1 (TTF-1) plays a critical role in ribosomal gene transcription. This transcription factor mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. It binds to and activates the promoter of thyroid specific genes such as thyroglobulin, thyrotropin receptor, and thyroperoxidase. TTF-1 is important in the maintenance of the thyroid differentiation phenotype.

Product Details
Technical data sheet

Product Details

Reactivity
Human, Rat
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
This antibody was developed using a rat TTF-1 recombinant protein.
Formulation
Phosphate-buffered solution with BSA + 0.1% NaN3.
Preparation
The antibody was purified by affinity chromatography.
Storage & Handling
Store between 2°C and 8°C.
Application

IHC-P - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, the antibody is ready-to-use.

Application Notes

The BioLegend TTF-1 (8G7G3/1) antibody recognizes the 40kD thyroid transcription factor, which is a member of the NKx2 family of transcription factors. TTF-1 antigen is expressed in epithelial cells of the thyroid gland and the lung.

RRID
AB_2565205 (BioLegend Cat. No. 918101)

Antigen Details

Biology Area
Cell Biology, Signal Transduction
Gene ID
25628 View all products for this Gene ID
UniProt
View information about TTF-1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 4    Revision Date: 12.06.2019

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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