- P88C12F4 (See other available formats)
- Regulatory Status
- Other Names
- RING1A, RNF1, Ring Finger Protein 1, E3 Ubiquitin Ligase RING1, EC:126.96.36.199, Really Interesting New Gene 1 Protein, RNF1
- Mouse IgG1, κ
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- Product Citations
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RING1 is an E3 ligase that is essential for development in higher eukaryotes and plants. It is a critical component of the Polycomb-group (PcG) multiprotein PRC1-like complex, which acts to transcriptionally repress genes through post- translational modifications that block the assembly of the transcriptional pre-initiation complex. As a component of PRC1, RING1 plays a pivotal role in monoubiquitination of Histone H2A at Lysine 119, which is linked to transcriptional repression of Hox family members.Product Details
- Human, Mouse
- Antibody Type
- Host Species
- Partial recombinant human RING1 protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.1 - 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This clone may cross-react with RING1B/RING2.
?Due to this clone binding to additional proteins of unknown origin by western blot, it was not tested for ICC.
AB_2861119 (BioLegend Cat. No. 936701)
AB_2861120 (BioLegend Cat. No. 936702)
- RING1 is a 406 amino acid protein with a predicted molecular weight of 55 kD.
RING1 expression is localized to the nucleus.
- Ubiquitin-protein ligase
- Biology Area
- Cell Biology, Chromatin Remodeling/Epigenetics, Ubiquitin/Protein Degradation
- Molecular Family
- Antigen References
- Akasaka T, et al. 2002. Genes Cells. 7:835-50.
- Levine SS, et al. 2002. Mol Cell Biol. 22:6070-8.
- Lovering R, et al. 1993. Proc Natl Acad Sci USA. 90:2112-6.
- Satijn DP, et al. 1997. Mol Cell Biol. 17:4105-13.
- Wang H, et al. 2004. Nature. 431:873-8.
- Gene ID
- 6015 View all products for this Gene ID
- View information about RING1 on UniProt.org
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