- A1 (See other available formats)
- Regulatory Status
- HCDM listed
- Other Names
- gp80, E-ATPDase, NTPDase-1, ecto-apyrase, Ec188.8.131.52
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
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Human CD39 is an integral membrane protein with two transmembrane domains. It exists as a homotetramer. Expression of CD39 is found on activated lymphocytes, a subset of T cells and B cells, and dendritic cells with weak staining on monocytes and granulocytes. CD39 and CD73 have been found on regulatory T cells, specifically the effector/memory like T cells. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. CD39 is the dominant ecto nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). CD39 has intrinsic ecto-ATPase activity. Expression of CD39 is induced on T cells and increased on B cells as a late activation antigen.Product Details
- Verified Reactivity
- Human, Cynomolgus, Rhesus
- Antibody Type
- Host Species
- PHA activated human lymphocytes
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA.
- The antibody was purified by affinity chromatography.
- 1.0 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
CyTOF®, IHC-P - Verified
- Recommended Usage
This product is suitable for use with the Maxpar® Metal Labeling Kits. For metal labeling using Maxpar® Ready antibodies, proceed directly to the step to Partially Reduce the Antibody by adding 100 µl of Maxpar® Ready antibody to 100 µl of 4 mM TCEP-R in a 50 kDa filter and continue with the protocol. Always refer to the latest version of Maxpar® User Guide when conjugating Maxpar® Ready antibodies.
- Application Notes
The A1 antibody binds to the human CD39 cell surface antigen and has been shown to block MHC independent target cell recognition by hapten-specific CTL. Additional reported applications (for the relevant formats) include: in vitro CD39 blockade3, immunofluorescence4, immunohistochemistry6, and spatial biology (IBEX)7,8. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for blocking assays (contact our custom solutions team).
- Additional Product Notes
Maxpar® is a registered trademark of Standard BioTools Inc.
(PubMed link indicates BioLegend citation)
- Aversa GG, et al. 1988. Transplant. P. 20:4952.
- Aversa GG, et al. 1989. Transplant. P. 21:34950.
- Borsellino G, et al. 2007. Blood. 110:1225. (Block)
- Stockl J, et al. 2001. J. Immunol. 167:2724. (IF)
- Sestak K, et al. 2007. Vet. Immunol. Immunopathol. 119:21.
- Lyck L, et al. 2008. J. Histochem. Cytochem. 56:201. (IHC)
- Radtke AJ, et al. 2020. Proc Natl Acad Sci USA. 117:33455-33465. (SB) PubMed
- Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
- Product Citations
AB_2563747 (BioLegend Cat. No. 328221)
Activated lymphocytes, and also on a subset of T cells, regulatory T cells, B cells, and dendritic cells.
- Cell Type
- B cells, Dendritic cells, Lymphocytes, T cells, Tregs
- Biology Area
- Molecular Family
- CD Molecules
- Gene ID
- 953 View all products for this Gene ID
- View information about CD39 on UniProt.org
Related Pages & Pathways
- Can I obtain CyTOF data related to your Maxpar® Ready antibody clones?
We do not test our antibodies by mass cytometry or on a CyTOF machine in-house. The data displayed on our website is provided by Fluidigm®. Please contact Fluidigm® directly for additional data and further details.
- Can I use Maxpar® Ready format clones for flow cytometry staining?
We have not tested the Maxpar® Ready antibodies formulated in solution containing EDTA for flow cytometry staining. While it is likely that this will work in majority of the situations, it is best to use the non-EDTA formulated version of the same clone for flow cytometry testing. The presence of EDTA in some situations might negatively affect staining.
- I am having difficulty observing a signal after conjugating a metal tag to your Maxpar® antibody. Please help troubleshoot.
We only supply the antibody and not test that in house. Please contact Fluidigm® directly for troubleshooting advice: http://techsupport.fluidigm.com/
- Is there a difference between buffer formulations related to Maxpar® Ready and purified format antibodies?
The Maxpar® Ready format antibody clones are formulated in Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA. The regular purified format clones are formulated in solution that does not contain any EDTA. Both formulations are however without any extra carrier proteins.
Other FormatsView All CD39 Reagents Request Custom Conjugation
|Brilliant Violet 510™ anti-human CD39||A1||FC|
|Brilliant Violet 421™ anti-human CD39||A1||FC,IHC-P|
|Purified anti-human CD39||A1||FC,IHC-P,Block|
|Biotin anti-human CD39||A1||FC|
|FITC anti-human CD39||A1||FC|
|PE anti-human CD39||A1||FC,SB|
|APC anti-human CD39||A1||FC|
|PE/Cyanine7 anti-human CD39||A1||FC|
|PerCP/Cyanine5.5 anti-human CD39||A1||FC|
|Purified anti-human CD39 (Maxpar® Ready)||A1||FC,CyTOF®,IHC-P|
|PE/Dazzle™ 594 anti-human CD39||A1||FC|
|APC/Cyanine7 anti-human CD39||A1||FC|
|Brilliant Violet 711™ anti-human CD39||A1||FC|
|APC/Fire™ 750 anti-human CD39||A1||FC|
|Alexa Fluor® 594 anti-human CD39||A1||IHC-P|
|TotalSeq™-A0176 anti-human CD39||A1||PG|
|Brilliant Violet 605™ anti-human CD39||A1||FC|
|TotalSeq™-C0176 anti-human CD39||A1||PG|
|Brilliant Violet 785™ anti-human CD39||A1||FC|
|TotalSeq™-B0176 anti-human CD39||A1||PG|
|TotalSeq™-D0176 anti-human CD39||A1||PG|
|PE/Fire™ 810 anti-human CD39 Antibody||A1||FC|
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
Brilliant Violet 510™ anti-human CD39
Brilliant Violet 421™ anti-human CD39
Purified anti-human CD39
Biotin anti-human CD39
FITC anti-human CD39
PE anti-human CD39
APC anti-human CD39
PE/Cyanine7 anti-human CD39
PerCP/Cyanine5.5 anti-human CD39
Purified anti-human CD39 (Maxpar® Ready)
PE/Dazzle™ 594 anti-human CD39
APC/Cyanine7 anti-human CD39
Brilliant Violet 711™ anti-human CD39
APC/Fire™ 750 anti-human CD39
Alexa Fluor® 594 anti-human CD39
TotalSeq™-A0176 anti-human CD39
Brilliant Violet 605™ anti-human CD39
TotalSeq™-C0176 anti-human CD39
Brilliant Violet 785™ anti-human CD39
TotalSeq™-B0176 anti-human CD39
TotalSeq™-D0176 anti-human CD39
PE/Fire™ 810 anti-human CD39 Antibody