- CBR-IC3/1 (See other available formats)
- Regulatory Status
- Other Names
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD50 is a 120-140 kD type I membrane protein also known as intercellular adhesion molecule 3 (ICAM-3). It is broadly expressed on leukocytes, endothelial cells, and Langerhans cells. CD50 is a member of the Ig superfamily. It provides costimulatory signal for T cells and regulates cell adhesion through interaction with LFA-1 (CD11a/CD18, αL/β2) integrin.Product Details
- Human, Baboon, Cynomolgus
- Antibody Type
- Host Species
- SKW3 cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Additional reported applications include: immunoprecipitation1 and blocking1-3.
(PubMed link indicates BioLegend citation)
- deFougerolles AR and Springer TA, et al. 1992. J. Exp. Med. 175:185. (IP, Block)
- Geijtenbeek T, et al. 2000. Cell 100:575. (Block)
- Giannoni E, et al. 2003. J Biol. Chem. 278:36763. (Block)
- Product Citations
AB_1186057 (BioLegend Cat. No. 330005)
- Ig superfamily, type I membrane protein, 130 kD
Thymocytes, T and B cells, monocytes, granulocytes, endothelial cells
- Adhesion, costimulation
- CD11a/CD18 (LFA-1), integrin αL/ß2
- Cell Type
- Thymocytes, T cells, B cells, Monocytes, Granulocytes, Endothelial cells
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Costimulatory Molecules
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Valent P, et al. 2001. Immunol. Rev. 179:74.
- Gene ID
- 3385 View all products for this Gene ID
- View information about CD50 on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
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