- 49.2 (See other available formats)
- Regulatory Status
- Other Names
- T Cell Receptor Vγ4
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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T cell receptor (TCR) is a heterodimer consisting of an α and β chain (TCR α/β) or a γ and δ chain (TCR γ/δ). TCR associates with CD3 to form a CD3/TCR complex. The CD3/TCR plays a key role in antigen recognition, signal transduction, and T cell activation. γδ T cells (gamma delta T cells) are a small subset of T cells that express a unique TCR. They are found in the thymus, peripheral lymphoid tissue, and peritoneum. Unlike αβ T cells, γδ T cells do not require antigen processing in order to recognize certain bacterial, lipid, and tumor antigens. The 49.2 antibody reacts specifically with mouse TCR Vγ4.Product Details
- Antibody Type
- Host Species
- C57BL/6 thymocytes expanded in vitro in anti-TCRγδ antibody coated plates
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Khairallah C, et al. 2015. PLoS Pathog. 11:e1004702.
- Perira P, et al. 2000. Eur J Immunol. 30:1988-97.
AB_2876572 (BioLegend Cat. No. 160602)
- Heterodimer with γ and δ chain
Subset of γδ T cells
- Antigen recognition
- Cell Type
- Lymphocytes, T cells, Thymocytes
- Biology Area
- Adaptive Immunity, Immunology, Innate Immunity
- Molecular Family
- Gene ID
- 21638 View all products for this Gene ID
- View information about TCR Vgamma4 on UniProt.org
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