Purified anti-human CD300c Antibody

Pricing & Availability
Clone
TX45 (See other available formats)
Regulatory Status
RUO
Other Names
LIR, CLM-6, CMRF35, IGSF16, CMRF-35, CMRF35A, CMRF-35A, CMRF35A1, CMRF35-A1
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
TX45_Pure_022309.jpg
Human peripheral blood monocytes stained with purified TX45, followed by anti-mouse IgG FITC
  • TX45_Pure_022309.jpg
    Human peripheral blood monocytes stained with purified TX45, followed by anti-mouse IgG FITC
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334802 100 µg 148,00€
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Description

CD300c, also known as CMRF-35-like molecule 6 (CLM-6) and leukocyte immunoglobulin-like receptor (LIR) is a 25 kD protein that belongs to the myeloid-associated immunoglobulin-like receptor (MAIR) family of genes. This transmembrane protein is expressed on certain B cells, T cells, NK cells, granulocytes, macrophages, monocytes, and mast cells. CD300C promotes secretion of proinflammatory cytokines and is an activating immune receptor associated ITAM-bearing adapter DAP12 and FcRγ chain on macrophages.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human, African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Simhadri VR, et al. 2013. J. Innate Immun. 4:389.
Product Citations
RRID
AB_2303773 (BioLegend Cat. No. 334802)

Antigen Details

Structure
Ig superfamily, 40 kD
Distribution
Monocytes/macrophages, dendritic cells
Function
Regulate myeloid cell activation and promote secretion of cytokines and chemokines
Interaction
DAP12, FcRγ
Cell Type
Monocytes, Macrophages, Dendritic cells
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules
Antigen References

1. Borrego F. 2013. Blood 11:1951.
2. Ju X, et al. 2009. Immunobiology 730-736.
3. Simhadri, et al. 2011. BMC Immunology 12:62.

Gene ID
10871 View all products for this Gene ID
UniProt
View information about CD300c on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 4    Revision Date: 07.06.2015

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

BioLegend Inc., 8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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