- B6.220 (See other available formats)
- Regulatory Status
- Other Names
- Insulin Receptor
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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CD220, also known as insulin receptor, is a type I transmembrane receptor tyrosine kinase composed of two extracellular α-subunits and two transmembrane β-subunits. Binding insulin, the insulin receptor forms a heterotetramer of two units to induce autophosphorylation and activation of the tyrosine kinase activity of the receptor. Activation of insulin receptor leads to subsequent downstream signaling in metabolic regulation, inducing glucose uptake, cell growth, differentiation, and apoptosis. Gene mutation in the insulin receptor or decreased insulin receptor signaling leads to insulin-resistant diabetes mellitus and noninsulin-dependent diabetes mellitus (diabetes mellitus type 2). Most normal cells constitutively express insulin receptors. In hematopoietic cells, insulin receptor is constitutively expressed on monocytes and selectively expressed on activated lymphocytes.Product Details
- Verified Reactivity
- Reported Reactivity
- African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Host Species
- Human insulin receptor/freund's adjuvant
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_10896052 (BioLegend Cat. No. 352602)
- Consist of two alpha subunits and two beta subunits; the beta subunit passes through the cellular membrane and is linked by disulfide bonds.
Hematopoietic and non hematopoietic cells.
- Regulates cell metabolism and growth.
- Ectonucleotide pyrophosphatase/phosphodiesterase, PTPN11, GRB10, GRB7, PRKCD, IRS1, SH2B1 and Mothers against decapentaplegic homolog 2.
- Biology Area
- Cell Biology, Immunology, Protein Synthesis, Signal Transduction
- Molecular Family
- CD Molecules, Protein Kinases/Phosphatase
- Antigen References
1. Viardot A, et al. 2006. Endocrinology 148:346.
2. Ward CW, et al. 2009. Bioessays 31:422.
3. Brindle NP, et al. 1990. Biochem. J. 268:615.
- Gene ID
- 3643 View all products for this Gene ID
- View information about CD220 on UniProt.org
Related Pages & Pathways
Other FormatsView All CD220 Reagents Request Custom Conjugation
|Purified anti-human CD220||B6.220||FC|
|PE anti-human CD220||B6.220||FC|
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