- TUGh4 (See other available formats)
- Regulatory Status
- VI C-89
- Other Names
- Common γ chain, γc, IL-2 receptor γ subunit
- Rat IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
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CD132 is a 64-70 kD type I transmembrane glycoprotein of the Ig superfamily, also known as common γ chain (γc), or IL-2 receptor γ subunit. It is expressed broadly on T- and B-lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21. Ligand binding induces tyrosine phosphorylation and initiates signaling through a JAK/STAT pathway. CD132 mutation results in X-linked severe combined immune deficiency (XSCID).Product Details
- Human, African Green, Cynomolgus, Rhesus
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Itano M, et al. 1996. J. Exp. Med. 178:389
- Kondo M, et al. 1993. Science 262:1874
AB_1279081 (BioLegend Cat. No. 338602)
- Type I transmembrane glycoprotein, Ig superfamily 64-70 kD
T cells, B cells, NK, monocytes, granulocytes
- Component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21
- Cell Type
- B cells, Granulocytes, Monocytes, NK cells, T cells
- Biology Area
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
1. Zola H, et al. eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication
2. Nakarai T, et al. 1994. J. Exp. Med. 180:241
3. Kawahara A, et al. 1995. Proc. Natl. Acad. Sci. USA. 92:8724
4. Habib T, et al. 2002. Biochemistry. 41:8725
5. Matthews DJ, et al. 1995. Blood 85:38
- Gene ID
- 3561 View all products for this Gene ID
- View information about CD132 on UniProt.org
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