PE anti-mouse TLT-2 Antibody

Pricing & Availability
Clone
MIH47 (See other available formats)
Regulatory Status
RUO
Other Names
TREML2, TREM-like transcript 2
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
A_MIH47_PE_011310
Mouse TLT-2 transfected cells stained with MIH47 PE
  • A_MIH47_PE_011310
    Mouse TLT-2 transfected cells stained with MIH47 PE
  • B_MIH47_011310
    C57BL/6 mouse splenocytes stained with MIH47
See PE spectral data
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136603 50 µg 117€
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Description

Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2, TREML2) is a type I transmembrane protein in TREM family. It consists of a single extracellular Ig-like domain of the V-type, a transmembrane domain, and a short cytoplasmic domain. TLT-2 is expressed on myeloid , B cells , and macrophages. It was also found to express on CD8+ T cells and activated CD4+ T cells. It regulates innate immune response based on its expression profile, costimulates the activation of T cells. Transduction of TLT-2 into T cells resulted in enhanced IL-2 and IFN-gamma production. It was reported that B3-H7 is a receptor of TLT-2. Blockade of the B7-H3/ TLT-2 pathway with monoclonal antibodies against B7-H3 or TLT-2 efficiently inhibited hypersensitivity response. Further studies are needed to confirm the ligand.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse TLT-2 Ig fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.06 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Hashiguchi M, et al. 2008. Proc. Nat. Acad. Sci. U. S. A. 105(30):10495
RRID
AB_2208701 (BioLegend Cat. No. 136603)

Antigen Details

Structure
A type I transmembrane protein in TREM family, consists of a single extracellular Ig-like domain of the V-type, a transmembrane domain, and a short cytoplasmic domain.
Distribution
Expressed on myeloid cells, B cells, macrophages, CD8+ T cells, and activated CD4+ T cells.
Function
Regulate innate immune response, IL-2, IFN-gamma production, and hypersensitivity response.
Cell Type
B cells, Macrophages, T cells
Biology Area
Immunology, Innate Immunity
Antigen References

1. King RG, et al. 2006. J. Immunol. 176:6012
2. Ford JW, et al. 2009. Curr Opin Immunol. 21(1):38
3. Leitner J, et al. 2009. Eur. J. Immunol. 39(7):1754

Gene ID
328833 View all products for this Gene ID
UniProt
View information about TLT-2 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11.30.2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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