- KJ16-133.18 (See other available formats)
- Regulatory Status
- Other Names
- T cell receptor Vβ8.1, 8.2 chain, TCR Vβ8.1, 8.2
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
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The TCR Vβ 8 family consists of three members, namely Vβ8.1, 8.2 and 8.3. KJ16-133.18 reacts with Vβ8.1, 8.2 only, but not Vβ8.3. Most mouse strains have about 20% Vβ 8+ T cells in the periphery.However, C57BR, C57L, SJL, SWR (Tcra haplotype) and RIII strains (Tcrc haplotype) do not express Vβ8 due to a gene deletion at the Vβ 8 family loci.Other strains expressing endogenous super-antigen, such as Mls-1a have significant reduced number of Vβ 8.1 cells in the periphery.Exogenous superantigen, such as staphylococcal enterotoxin B, stimulates lymphocytes bearing Vβ 8 and selectively eliminate those T cells in vivo.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- TCR receptor from T cell hybridoma DO-11.10
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Blue Laser (488 nm)
(PubMed link indicates BioLegend citation)
- Reider SA, et al. 2011. Infect Immun. 79:3141. PubMed.
- Product Citations
AB_1227787 (BioLegend Cat. No. 118405)
AB_1227786 (BioLegend Cat. No. 118406)
- TCR is a 85-kd hetero-dimer composed of alpha and beta chain. The mouse Vβ8 family has three members, namely Vβ8.1, 8.2 and 8.3.
Expressed on α:β T cells in mouse thymus, spleen and other lymphoid organs.
- Recognition of peptide/ MHC
- CD3, CD4, CD8
- Cell Type
- T cells
- Biology Area
- Adaptive Immunity, Immunology
- Molecular Family
- Antigen References
1. Haskins K, et al. 1984. J. Exp. Med. 160:452
2. Behlke MA, et al. 1986. P. Natl. Acad. Sci. USA 83:767
3. Fairchild S, et al. 1992. 36:189
4. White J, et al. 1989. Cell 56:27
- Gene ID
- 21577 View all products for this Gene ID
- View information about TCR Vbeta8.1 8.2 on UniProt.org
Related Pages & Pathways
Other FormatsView All TCR Vβ8.1, 8.2 Reagents Request Custom Conjugation
|Purified anti-mouse TCR Vβ8.1, 8.2||KJ16-133.18||FC,IP|
|FITC anti-mouse TCR Vβ8.1, 8.2||KJ16-133.18||FC|
|PE anti-mouse TCR Vβ8.1, 8.2||KJ16-133.18||FC|
|Alexa Fluor® 647 anti-mouse TCR Vβ8.1, 8.2||KJ16-133.18||FC|
|TotalSeq™-B0235 anti-mouse TCR Vβ8.1, 8.2||KJ16-133.18||PG|
|TotalSeq™-C0235 anti-mouse TCR Vβ8.1, 8.2||KJ16-133.18||PG|
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