APC anti-mouse CD205 (DEC-205) Antibody

Pricing & Availability
NLDC-145 (See other available formats)
Regulatory Status
Other Names
Rat IgG2a, κ
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Product Citations
C57BL/6 bone marrow cells stained with Gr-1 (RB6-8C5) FITC and NLDC-145 APC
  • NLDC-145_APC_1_062410
    C57BL/6 bone marrow cells stained with Gr-1 (RB6-8C5) FITC and NLDC-145 APC
  • NLDC-145_APC_2_062410
    C57BL/6 bone marrow cells stained with Gr-1(RB6-8C5) FITC and rat IgG2a APC isotype control
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138205 25 µg 100,00€
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138206 100 µg 228,00€
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CD205, also known as DEC-205, is a 205 kD integral membrane protein homologous to the macrophage mannose receptor. It is a type I cell surface protein that belong to the C-type lectin family.  CD205 is expressed at high levels by dendritic cells and thymic epithelial cells.  It is also expressed by a number of other cell types, such as B lymphocytes, macrophages, Langerhans cells, bone marrow stromal cells, granulocytes, epithelial cells of pulmonary airways, and the capillaries of the brain.  CD205 is a novel endocytic receptor used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to specialized antigen processing.  It mediates antigen uptake and presentation and cross-presentation to T cells.  It has been reported that CD205 acts as a recognition receptor for dying cells, potentially provides an important pathway for the uptake of self-antigen in the intrathymic environment, and is involved in peripheral tolerance.  Antibody-mediated antigen-targeting via the DEC-205 receptor increases the efficiency of vaccination for T cell immunity.

Product Details
Technical Data Sheet (pdf)

Product Details

Antibody Type
Host Species
Mouse lymph node tissue
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.06 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections1, Western Blot1-3, and immunoprecipitation of bone marrow dendritic cell extracts2.

Application References

(PubMed link indicates BioLegend citation)
  1. Witmer-Pack MD, et al. 1995. Cell. Immun. 163:157. (IHC, WB)
  2. Swiggard WJ, et al. 1995. Cell. Immun. 165:302. (WB, IP)
  3. Bonifaz LC, et al. 2004. J. Exp. Med. 199:815. (WB)
  4. Yamazaki S, et al. 2002. J. Immunol. 181:6923. (FC)
  5. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC)
Product Citations
  1. Nechama M, et al. 2018. Nat Commun. 9:1603. PubMed
  2. Scarlett U, et al. 2012. J Exp Med. 209:425. PubMed
  3. Wallner S, et al. 2013. PLoS One. 8:65178. PubMed
  4. Shin C, et al. 2016. Immunol Lett. 172: 21-28. PubMed
AB_10612574 (BioLegend Cat. No. 138205)
AB_10613641 (BioLegend Cat. No. 138206)

Antigen Details

A 205 kD type I tramsmembrane protein belonging to the C-type lectin family and homologous to the macrophage mannose receptor.

Expressed at high levels by dendritic cells and thymic epithelial cells. Also expressed by B lymphocytes, macrophages, Langerhans cells, bone marrow cells and epithelial cells.

Mediates endocytosis, antigen uptake, presentation, and cross-presentation to T cells.
Cell Type
B cells, Dendritic cells, Epithelial cells, Langerhans cells, Macrophages
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity
Molecular Family
CD Molecules
Antigen References

1. Jiang WP, et al. 1995. Nature 375:151.
2. Small M and Kraal G. 2003. Int. Immunol. 15:197.
3. Shrimpton RE, et al. 2009. Mol. Immunol. 46:1229.

Gene ID
17076 View all products for this Gene ID
View information about CD205 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11.30.2012

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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