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PE anti-human CD66c Antibody

Pricing & Availability
Clone
W20030E (See other available formats)
Regulatory Status
RUO
Other Names
Carcinoembryonic antigen-related cell adhesion molecule 6
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
W20030E_PE_CD66c_Antibody_030623
Human peripheral blood granulocytes were stained with anti-human CD66c (clone W20030E) PE (filled histogram) or rat IgG2a, κ PE isotype control (open histogram).
  • W20030E_PE_CD66c_Antibody_030623
    Human peripheral blood granulocytes were stained with anti-human CD66c (clone W20030E) PE (filled histogram) or rat IgG2a, κ PE isotype control (open histogram).
See PE spectral data
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386105 25 tests $120
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386106 100 tests $285
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Description

Carcinoembryonic antigen (CEA) Cell Adhesion Molecule 6 (CEACAM6) belongs to the (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. As a cell adhesion molecule, CEACAM6 mediates homotypic binding with other CEA family members and heterotypic binding with integrin receptors. CEACAM6 is expressed on epithelial surfaces and in the myeloid lineage. Despite lacking transmembrane and intracellular domains, GPI-anchored proteins, including CEACAM family members, are able to influence transmembrane signaling via tyrosine kinases. CEACAM6 modulates c-Src tyrosine kinase activity. Overexpressed in more than 50% of all human adenocarcinomas, CEACAM6 promotes aberrant cell differentiation, anti-apoptosis, cell growth and resistance to therapeutic agents, cell invasion and metastasis.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant protein, aa 35-320
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID
AB_3068032 (BioLegend Cat. No. 386105)
AB_3068032 (BioLegend Cat. No. 386106)

Antigen Details

Structure
Glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins Immunoglobulin superfamily
Distribution

Apical Cell Membrane

Function
The extracellular N-terminus Ig-like V-type domain is necessary for homophilic and heterophilic intercellular adhesion.
Interaction
Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8
Cell Type
Epithelial cells, Granulocytes
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References
  1. Duxbury MS, et al. 2004. Oncogene. 23:465-73.
  2. Oikawa S, et al. 1991. J Biol Chem. 266:7995-8001.
  3. Noworolska A, et al. 1986. Cancer Detect Prev. 9:365-71.
  4. Wu S, et al. 2021. Transl Oncol. 14:101057
Gene ID
4680 View all products for this Gene ID
UniProt
View information about CD66c on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 03/06/2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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