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- Clone
- No.5/FOLR (See other available formats)
- Regulatory Status
- RUO
- Other Names
- FR-αβ
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human FR-β transfected cells were stained with FOLRα/β (No.5/FOLR) (filled histogram) or Rat IgG2a, κ isotype control (open histogram), followed by goat-anti-Rat IgG PE. -
Human epidermal carcinoma cells (KB cell line) were stained with FOLRα/β (No.5/FOLR) (filled histogram) or Rat IgG2a, κ isotype control (open histogram), followed by goat-anti-Rat IgG PE.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 391802 | 100 µg | $241 | ||||
Human folate receptors alpha and beta (FR-α and FR-β) are members of a family of folate binding receptors that have diverse structural identities but mediate transport of folates into cells. The FR-α and FR-β isoforms are both GPI-anchored proteins with high affinity for folic acid. It is postulated that these receptors function as folate scavengers when folate supply is low or rapid cell growth requires elevated uptake of folate for methylation reactions including DNA biosynthesis. The expression of FR-α and FR-β are distinct in normal and malignant tissues. In normal tissue, FR-α is mainly expressed on the surface of a subset of polarized epithelial cells whereas its aberrant expression has been prominently correlated with malignancies of epithelial origin. Although the FR-β protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Reported Reactivity
- Monkey
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Human Folate beta transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This clone reacts with both Human FOLR1 and FOLR2
-
Application References
(PubMed link indicates BioLegend citation) -
- Nagai T, et al. 2015. Monoclon. Antib. Immunodiagn. Immunother. 34:181
- Product Citations
-
- RRID
-
AB_2715779 (BioLegend Cat. No. 391802)
Antigen Details
- Structure
- 30 kD, seven disulfide bonds
- Distribution
-
Epithelial cells and same type of tumor cells
- Function
- Transport of folate into cells
- Ligand/Receptor
- Folic Acid
- Cell Type
- Epithelial cells
- Biology Area
- Cancer Biomarkers, Cell Biology, Immunology
- Antigen References
-
1. Elwood PC, 1989. J Biol Chem. 264:14893
2. Shen F, et al. 1994. Biochemistry. 33:1209-15
3. Yi YS, 2016. Immune Netw. 16:337 - Gene ID
- 2348 View all products for this Gene ID 2350 View all products for this Gene ID
- UniProt
- View information about FR-alphabeta on UniProt.org
Related FAQs
Other Formats
View All FR-αβ Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human Folate Receptors α and β (FR-αβ) | No.5/FOLR | FC |
| PE anti-human Folate Receptors α and β (FR-αβ) | No.5/FOLR | FC |
| APC anti-human Folate Receptors α and β (FR-αβ) | No.5/FOLR | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human Folate Receptors α and β (FR-αβ)
Human FR-β transfected cells were stained with FOLRα/β (No.5... 
Human epidermal carcinoma cells (KB cell line) were stained ... -
PE anti-human Folate Receptors α and β (FR-αβ)
Human epidermal carcinoma cells (KB cell line) were stained ... 
Human FR-β transfected cells were stained with PE anti-human... -
APC anti-human Folate Receptors α and β (FR-αβ)
Human epidermal carcinoma cells (KB cell line) were stained ... 
Human FR-β transfected cells were stained with PE anti-human...
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