- 3G7A02 (See other available formats)
- Regulatory Status
- Other Names
- TNFRSF1B, p75, p75TNFR, TNFR2, TNFR80, TBPII
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
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CD120b, also known as TNFRII or TNFRSF1B, belongs to the TNF receptor superfamily and can interact with ligands TNF-α and TNF-β (also known as LT-α). It is a 75 kD type I transmembrane protein expressed on lymphocytes, monocytes, and granulocytes. When present in a heterocomplex with CD120a, it induces the recruitment of anti-apoptotic molecules, c-IAP1 and c-IAP2 that possess E3 ubiquitin ligase activity. Mutations in CD120b are associated with TNF-associated periodic syndrome (TRAPS) or periodic fever syndrome.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Partial CD120b recombinant protein expressed in 293E cells (22-211aa).
- 0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/µg of the protein (<0.001 ng/µg of the protein) as determined by the LAL test.
- The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
FC, Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralization. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_2563224 (BioLegend Cat. No. 358408)
- 75 kD, type I transmembrane protein, member of the TNF-receptor superfamily, forms a heterocomplex with TNFRI
Expressed on cells of hematopoietic lineage including monocytes, lymphocytes, and granulocytes
- When complexed with TNFRI, recruits anti-apoptotic molecules c-IAP1 and c-IAP2 that possess ubiquitin ligase activity; cysteine rich extracellular region
- Interacts with TTRAP and TRAF2
- TNF-α and TNF-β (LT-α)
- Cell Type
- Granulocytes, Lymphocytes, Monocytes
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Transcription Factors
- Molecular Family
- CD Molecules
- Antigen References
1. Andrews JS, et al. 1990. J. Immunol. 144:2582.
2. Nophar Y, et al. 1990. EMBO J. 9:3269.
3. Kohno T, et al. 1990. Proc. Natl. Acad. Sci. USA 87:8331.
4. Tartaglia LA, et al. 1991. Proc. Natl. Acad. Sci. USA 88:9292.
5. Hijdra D, et al. 2012. J. Inflamm. (Lond). 9:38.
6. Chen X, et al. 2013. J. Immunol. 190:1076.
- Gene ID
- 7133 View all products for this Gene ID
- View information about CD120b on UniProt.org
- Do you guarantee that your antibodies are totally pathogen free?
BioLegend does not test for pathogens in-house aside from the GoInVivo™ product line. However, upon request, this can be tested on a custom basis with an outside, independent laboratory.
- Does BioLegend test each Ultra-LEAF™ antibody by functional assay?
No, BioLegend does not test Ultra-LEAF™ antibodies by functional assays unless otherwise indicated. Due to the possible complexities and variations of uses of biofunctional antibodies in different assays and because of the large product portfolio, BioLegend does not currently perform functional assays as a routine QC for the antibodies. However, we do provide references in which the antibodies were used for functional assays and we do perform QC to verify the specificity and quality of the antibody based on our strict specification criteria.
- Does BioLegend test each Ultra-LEAF™ antibody for potential pathogens?
No, BioLegend does not test for pathogens in-house unless otherwise indicated. However, we can recommend an outside vendor to perform this testing as needed.
- Have you tested this Ultra-LEAF™ antibody for in vivo or in vitro applications?
We don't test our antibodies for in vivo or in vitro applications unless otherwise indicated. Depending on the product, the TDS may describe literature supporting usage of a particular product for bioassay. It may be best to further consult the literature to find clone specific information.
|Purified anti-human CD120b||3G7A02||FC|
|PE anti-human CD120b||3G7A02||FC|
|APC anti-human CD120b||3G7A02||FC|
|Ultra-LEAF™ Purified anti-human CD120b||3G7A02||Neut, FC|
|Biotin anti-human CD120b||3G7A02||FC|
|PE/Cyanine7 anti-human CD120b||3G7A02||FC|
|PE/Dazzle™ 594 anti-human CD120b||3G7A02||FC|
|TotalSeq™-A1024 anti-human CD120b||3G7A02||PG|
|TotalSeq™-C1024 anti-human CD120b||3G7A02||PG|
|TotalSeq™-D1024 anti-human CD120b Antibody||3G7A02||PG|
|TotalSeq™-B1024 anti-human CD120b||3G7A02||PG|
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Purified anti-human CD120b
PE anti-human CD120b
APC anti-human CD120b
Ultra-LEAF™ Purified anti-human CD120b
Biotin anti-human CD120b
PE/Cyanine7 anti-human CD120b
PE/Dazzle™ 594 anti-human CD120b
TotalSeq™-A1024 anti-human CD120b
TotalSeq™-C1024 anti-human CD120b
TotalSeq™-D1024 anti-human CD120b Antibody
TotalSeq™-B1024 anti-human CD120b