Purified anti-human CD98 Antibody

Pricing & Availability
MEM-108 (See other available formats)
Regulatory Status
Other Names
4F2, FRP-1, RL-388
Mouse IgG1, κ
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Product Citations
Human peripheral blood lymphocytes stained with purified MEM-108, followed by anti-mouse IgGs FITC
  • MEM-108_Purified_070507
    Human peripheral blood lymphocytes stained with purified MEM-108, followed by anti-mouse IgGs FITC
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315602 100 µg 90€
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CD98 is a 125 kD disulfide-linked heterodimer protein also known as 4F2 and FRP-1. It is broadly expressed on activated and transformed cells (hematopoietic and non-hematopoietic), and at low levels on quiescent cells. CD98 has been characterized as a potential amino acid transporter (neutral and dibasic amino acids) that is involved in lymphocyte activation and integrin signaling. CD98 is composed of a light chain (45 kD) and a heavy chain (80 kD). Studies with knock-out mice indicate that the CD98 heavy chain is involved in integrin-dependent cell spreading and protection against anchorage deprivation-induced apoptosis. The MEM-108 antibody is useful for flow cytometry and immunoprecipitation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Antibody Type
Host Species
Burkitt's lymphoma cell line Raji
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested
IP - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation.

Application References
  1. Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. New York.
  2. Cantor J, et al. 2011. J. Immunol. 187:851. PubMed.
Product Citations
  1. Weng L, et al. 2018. PLoS Biol. 7:e1428158. PubMed
  2. Feliciano D, et al. 2021. Nat Commun. 12:4502. PubMed
  3. Wunderley L, et al. 2021. J Cell Sci. . PubMed
  4. Wunderley L, et al. 2021. J Cell Sci. 134:. PubMed
  5. Higashi S, et al. 2022. J Cell Sci. 135:. PubMed
  6. Arndt C, et al. 2020. Oncoimmunology. 9:1743036. PubMed
  7. Cantor J, et al. 2011. J Immunol. 187:851. PubMed
AB_2302070 (BioLegend Cat. No. 315602)

Antigen Details

Disulfide-linked heterodimer, 80 kD and 45 kD reduced, 125 kD unreduced

Broadly expressed on activated and transformed cells, not hematopoietic cell-specific. Lower levels on resting cells

Potential amino acid transporter (neutral and dibasic amino acids) also involved in the activation of lymphocytes and integrin signaling. May be a target antigen for NK cells
Actin, β1 integrins (α2β1, α3β1, α5β1, α6β1; minimally with α4β1)
Glycosylated (heavy chain)
Biology Area
Molecular Family
CD Molecules
Antigen References

1. Leukocyte Typing VI. Kishimoto T, et al. (Eds.) Garland Publishing Inc. (1997)
2. Bron C, et al. 1986. J. Immunol. 137:397.
3. Lumadue JA, et al. 1987. Proc. Natl. Acad. Sci. 84:9204.
4. Mastroberardino L, et al. 1998. Nature 395:288.

Gene ID
6520 View all products for this Gene ID
View information about CD98 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11-30-2012

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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