Purified anti-CCL11 (Eotaxin) Antibody

Pricing & Availability
Clone
16D10A40 (See other available formats)
Other Names
Eotaxin-1, small inducible cytokine subfamily A, member 11 (SCYA11)
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
16D10A40_CCL11_Purified_Antibody_WB_012114.jpg
Western blot analysis of recombinant human CCL11(lane 1) and recombinant mouse CCL11 (lane 2) using anti-CCL11 antibody(16D10A40).
  • 16D10A40_CCL11_Purified_Antibody_WB_012114.jpg
    Western blot analysis of recombinant human CCL11(lane 1) and recombinant mouse CCL11 (lane 2) using anti-CCL11 antibody(16D10A40).
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656701 500 µg 200€
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Description

CCL11 is a member of the CC chemokine family and was originally identified as a chemoattractant for eosinophils. In response to allergens, CCL11, which participates in a variety of allergic diseases, promotes accumulation of eosinophils. CCL11 production is upregulated in response to several proinflammatory cytokines, such as IL-4, IL-13, TNF-α, and IFN-α, produced by mast cells and Th2 lymphocytes. CCL11 has been reported to stimulate eosinophil release from bone marrow, resulting in an elevated level of circulating eosinophils. In addition, CCL11 facilitates proliferation and metastasis of tumor cells expressing the CCL11 receptor, CCR3. CCL11 has been shown to induce an angiogenic response by CCR3-positive microvascular endothelial cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Human CCL11 recombinant protein (Gly24-Pro97) expressed in E. coli
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2562411 (BioLegend Cat. No. 656701)

Antigen Details

Distribution
Secreted; Expressed in epithelial cells, smooth muscle cells, dendritic cells, and fibroblasts
Function
CCL11 selectively recruits eosinophils through binding to the chemokine receptor CCR3 during allergic response.
Interaction
Eosinophils
Ligand/Receptor
CCR3
Cell Type
Epithelial cells, Dendritic cells, Fibroblasts, Eosinophils
Biology Area
Angiogenesis, Cell Biology, Immunology, Neuroinflammation, Neuroscience
Molecular Family
Cytokines/Chemokines
Antigen References

1. Conroy DM, et al. 2001. Respir. Res. 2:150.
2. Levina V, et al. 2009. Clin. Cancer Res. 15:2647.
3. Salcedo R, et al. 2001. J. Immunol. 166:7571.
4. Kaehler J, et al. 2006. J. Investig. Med. 54:446.
5. Hadjicharalambous C, et al. 2004. J. Allergy Clin. Immunol. 113:657.
6. Crump MP, et al. 1998. J. Biol. Chem. 273:22471.

Gene ID
6356 View all products for this Gene ID
UniProt
View information about CCL11 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 01-21-2014

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