- S18009F (See other available formats)
- Regulatory Status
- Other Names
- T200, Ly-5, LCA
- Rat IgG2b, κ
- Ave. Rating
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- Product Citations
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CD45 is a 180-240 kD glycoprotein also known as the leukocyte common antigen (LCA), T200, or Ly-5. It is a member of the protein tyrosine phosphatase (PTP) family, expressed on all hematopoietic cells except mature erythrocytes and platelets. There are different isoforms of CD45 that arise from variable splicing of exons 4, 5, and 6, which encode A, B, and C determinants, respectively. CD45 plays a key role in TCR and BCR signal transduction. These isoforms are very specific to the activation and maturation state of the cell as well as cell type. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4, TCR, CD22, and Thy-1.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Recombinant mouse CD45
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography and conjugated with PE/Fire™ 810 under optimal conditions.
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
* PE/Fire™ 810 has a maximum excitation of 488/561 nm and a maximum emission of 810 nm.
Excessive exposure to light, and commonly used fixation, permeabilization buffers can affect PE/Fire™ 810 fluorescence signal intensity and spread. Please keep conjugates protected from light exposure. For more information and representative data, visit our Fire Dyes page.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
AB_2894659 (BioLegend Cat. No. 157215)
- Protein tyrosine phosphatase (PTP) family, 180-240 kD
All hematopoietic cells except mature erythrocytes and platelets
- Phosphatase, T and B cell activation
- Mesenchymal Stem Cells, B cells, Dendritic cells, Tregs
- Galectin-1, CD2, CD3, CD4, TCR, CD22, Thy-1
- Biology Area
- Cell Biology, Immunology, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
- Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
- Trowbridge IS, et al. 1994. Annu. Rev. Immunol. 12:85.
- Kishihara K, et al. 1993. Cell. 74:143.
- Pulido R, et al. 1988. J. Immunol. 140:3851.
- Gene ID
- 19264 View all products for this Gene ID
- View information about CD45 on UniProt.org
Related Pages & Pathways
Other FormatsView All CD45 Reagents Request Custom Conjugation
|Purified anti-mouse CD45||S18009F||FC|
|APC/Cyanine7 anti-mouse CD45||S18009F||FC|
|PE/Cyanine7 anti-mouse CD45||S18009F||FC|
|PerCP/Cyanine5.5 anti-mouse CD45||S18009F||FC|
|Alexa Fluor® 700 anti-mouse CD45||S18009F||FC|
|Pacific Blue™ anti-mouse CD45||S18009F||FC|
|PE/Fire™ 810 anti-mouse CD45||S18009F||FC|
|FITC anti-mouse CD45||S18009F||FC|
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