PE/Cyanine7 anti-mouse CD38 Antibody

Pricing & Availability
Clone
90 (See other available formats)
Other Names
T10
Isotype
Rat IgG2a, κ
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Product Citations
publications
90_PECy7_011108
C57BL/6 mouse splenocytes stained with 90 PE/Cyanine7
  • 90_PECy7_011108
    C57BL/6 mouse splenocytes stained with 90 PE/Cyanine7
See PE/Cyanine7 spectral data
Cat # Size Price Quantity Avail. Save
102717 25 µg 72€
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102718 100 µg 220€
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Description

CD38 is a 42 kD glycoprotein, also known as T10. It is an ADP-ribosyl hydrolase, expressed on B cells, NK cells, a subset of T cells, brain, muscle, and kidney. In mouse, CD38 expression is downregulated on germinal center B cells and plasma cells, whereas this is not the case for humans. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, as well as adhesion and metabolism of cADPR and NAADP. CD31 is the ligand of CD38.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse bone marrow pre-B cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemistry1,2 of acetone-fixed frozen sections, and induction of B cell proliferation1.

Additional Product Notes
BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.
Application References
  1. Oliver AM, et al. 1997. J. Immunol. 158:1108.
  2. Howard M, et al. 1993. Science 262:1056.
Product Citations
  1. Degn SE et al. 2017. Cell. 170(5):913-926 . PubMed
  2. Firl DJ et al. 2018. eLife. 7 pii: e33051. PubMed
  3. Abbott RK, et al. 2018. Immunity. 48:133. PubMed
  4. Teo TH, et al. 2018. Nat Commun. 9:3905. PubMed
  5. Andersen TK, et al. 2019. NPJ Vaccines. 4:9. PubMed
  6. Kim CC et al. 2019. Cell Rep. 27(5):1446-1460 . PubMed
  7. Chen J et al. 2018. Cell reports. 25(12):3393-3404 . PubMed
  8. Mintz MA, et al. 2019. Immunity. 51:310. PubMed
  9. Ise W, et al. 2018. Immunity. 48:702. PubMed
  10. Hilpert C, et al. 2019. J Immunol. 203:3068. PubMed
  11. van der Poel CE, et al. 2019. Cell Rep. 29:2745. PubMed
  12. Mesin L, et al. 2020. Cell. 180(1):92-106.e11.. PubMed
  13. Singh KS, et al. 2020. Nat Commun. 0.786805556. PubMed
  14. Riedel R, et al. 2020. Nat Commun. 11:2570. PubMed
  15. Shi B, et al. 2018. J Immunol. 200:586. PubMed
  16. Hudson WH, et al. 2020. Immunity. 51(6):1043-1058.e4.. PubMed
  17. Ly A, et al. 2020. Cell Reports. 29(8):2257-2269.e6.. PubMed
  18. Yu M, et al. 2012. Proc Natl Acad Sci U S A. 109:E879. PubMed
  19. Kaji T, et al. 2012. J Exp Med. 209:2079. PubMed
  20. Kajikawa A, et al. 2015. PLoS One. 10: e0141713. PubMed
  21. Muppidi J, et al. 2015. J Exp Med. 212: 2213 - 2222. PubMed
  22. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  23. Ryg-Cornejo V, et al. 2016. Cell Rep. 14:68-81. PubMed
  24. Hilpert C, et al. 2016. J Immunol. 197: 2780 - 2786. PubMed
RRID
AB_2072892 (BioLegend Cat. No. 102717)
AB_2275531 (BioLegend Cat. No. 102718)

Antigen Details

Structure
ADP-ribosyl hydrolase, 42 kD
Distribution

B cells, NK cells, T cell subset, brain, muscle, kidney

Function
Regulation of cellular activation/proliferation, adhesion, metabolism of cADPR and NAADP
Ligand/Receptor
CD31, hyaluronic acid
Cell Type
B cells, NK cells, T cells
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Shubinsky G, et al. 1997. Immunity 7:315.
3. Cesano A, et al. 1998. J. Immunol. 160:1106.
4. Cockayne DA, et al. 1998. Blood 92:1324.

Gene ID
12494 View all products for this Gene ID
UniProt
View information about CD38 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11-30-2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

BioLegend Inc., 8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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