PE anti-mouse CD206 (MMR) Antibody

Pricing & Availability
Clone
C068C2 (See other available formats)
Regulatory Status
RUO
Other Names
MMR (macrophage mannose receptor), MR (mannose receptor), MRC1
Isotype
Rat IgG2a, κ
Ave. Rating
Submit a Review
Product Citations
publications
C068C2_PE_1_082911
Thioglycollate-elicited BALB/c peritoneal macrophages were surface stained with CD107b (Mac-3) APC, and then intracellularly stained with CD206 (clone C068C2) PE (top) or rat IgG2a, κ PE isotype control (bottom).
  • C068C2_PE_1_082911
    Thioglycollate-elicited BALB/c peritoneal macrophages were surface stained with CD107b (Mac-3) APC, and then intracellularly stained with CD206 (clone C068C2) PE (top) or rat IgG2a, κ PE isotype control (bottom).
  • C068C2_PE_2_082911
Compare all formats See PE spectral data
Cat # Size Price Quantity Check Availability Save
141705 25 µg 104€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
141706 100 µg 240€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant mouse CD206 (MMR)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested
FC - Verified

Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume.  It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone C068C2 recognizes a region similar to clone MR5D3, based on the ability of the clones to block each other. Additional reported applications (for the relevant formats) include: spatial biology (IBEX)4,5.

Application References
  1. Keller J, et al. 2012. Biochem Biophys Res Commun. 417:217. PubMed
  2. Ito H, et al. 2012. J Am Soc Nephrol. 23:1797. PubMed
  3. Yang X, et al. 2015. PNAS. 112:2900. PubMed
  4. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  5. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Michela Miani et al. 2018. Cell metabolism. 28(4):557-572 . PubMed
  2. Feng Y, et al. 2018. J Am Soc Nephrol. 29:182. PubMed
  3. Seo JB, et al. 2019. Nat Metab. 1:86. PubMed
  4. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  5. Sun H, et al. 2019. Mol Hum Reprod. 25:05:00. PubMed
  6. Xiong Y, et al. 2020. J Nanobiotechnology. 18:66. PubMed
  7. Cui J, et al. 2021. J Cell Mol Med. 25:5586. PubMed
  8. Zhang B, et al. 2022. Front Med (Lausanne). 8:796743. PubMed
  9. Zhang Z, et al. 2022. Front Pharmacol. 13:906625. PubMed
  10. Hu S, et al. 2018. Front Immunol. 9:01. PubMed
  11. Ying W et al. 2017. Cell. 171(2):372-384 . PubMed
  12. Tripathi H, et al. 2020. J Mol Cell Cardiol. 149:95. PubMed
  13. Clarke F,et al. 2017. PLoS One. 10.1371/journal.pone.0186625. PubMed
  14. Zhang Y, et al. 2018. Sci Rep. 8:5994. PubMed
  15. Hsu SPC, et al. 2020. J Neurooncol. 146:417. PubMed
  16. Nomura M, et al. 2016. Nat Immunol. 17:216-217. PubMed
  17. Leach SM, et al. 2020. Cell Rep. 33:108337. PubMed
  18. Zheng W, et al. 2021. Wellcome Open Research. 6:52. PubMed
  19. Uzhachenko RV, et al. 2021. Cell Reports. 35(1):108944. PubMed
  20. Dong L, et al. 2021. Cancer Cell. . PubMed
  21. Sadek J, et al. 2021. EMBO Mol Med. 13:e13591. PubMed
  22. Li Q, et al. 2021. Front Immunol. 12:707784. PubMed
  23. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  24. De Vlaeminck Y, et al. 2020. Cancers (Basel). 12:. PubMed
  25. Li J, et al. 2021. Front Immunol. 12:649285. PubMed
  26. Krukowski K, et al. 2021. Sci Adv. 7:eabg6702. PubMed
  27. Pajarinen J, et al. 2021. J Biomed Mater Res A. 109:1512. PubMed
  28. Shao H, et al. 2012. J Biol Chem. 287:35860. PubMed
  29. Mul Fedele ML, et al. 2020. Front Cell Infect Microbiol. 10:100. PubMed
  30. El–Achkar GA, et al. 2019. PLoS One. 14:e0216405. PubMed
  31. He C, et al. 2021. Oncoimmunology. 1897295:10. PubMed
  32. Tang TT, et al. 2020. Sci Adv. 6:eaaz0748. PubMed
  33. Zhang J, et al. 2021. J Leukoc Biol. 110:485. PubMed
  34. Tanner L, et al. 2022. Front Pharmacol. 13:899469. PubMed
  35. Hou H, et al. 2021. Front Cell Dev Biol. 9:737003. PubMed
  36. Johansen AZ, et al. 2022. Pharmaceutics. 14:. PubMed
  37. Jia X, et al. 2021. Front Cell Dev Biol. 9:685522. PubMed
  38. Giri J, et al. 2020. Cell Rep. 30:1923. PubMed
  39. Dan H, et al. 2020. Mol Oncol. 14:795. PubMed
  40. Kim JS, et al. 2020. Int J Oncol. 56:1405. PubMed
  41. McKee AM, et al. 2021. iScience. 24:103012. PubMed
  42. Zhang Y, et al. 2022. Nat Commun. 13:4553. PubMed
  43. Rao X, et al. 2022. Cell Death Dis. 13:891. PubMed
  44. Farini A, et al. 2020. Front Physiol. 0.738194444. PubMed
  45. An W et al. 2019. British journal of pharmacology. 176(5):699-710 . PubMed
  46. Martins L, et al. 2020. Stem Cell Res Ther. 0.786805556. PubMed
  47. Li J, et al. 2021. Cell Commun Signal. 19:89. PubMed
  48. Mehta AK, et al. 2021. Nat Cancer. 2:66. PubMed
  49. Jiao Y, et al. 2021. Crit Care. 25:356. PubMed
  50. Guérin MV, et al. 2019. Nat Commun. 10:4131. PubMed
  51. Liao T, et al. 2017. Front Immunol. 8:1334. PubMed
  52. Wang J, et al. 2021. Nat Commun. 12:6198. PubMed
  53. Lu X, et al. 2020. Sci Transl Med. 12:. PubMed
  54. Lee DH, et al. 2019. PLoS One. 14:e0215727. PubMed
  55. Yu Y, et al. 2018. Mol Med Rep. 17:8212. PubMed
  56. Toubal A, et al. 2020. Nat Commun. 3755:11. PubMed
  57. Tacconi C, et al. 2021. Cell Reports. 35(2):108993. PubMed
  58. Wei W, et al. 2022. mSystems. 7:e0046922. PubMed
  59. Wang Y, et al. 2022. Cell Death Dis. 13:748. PubMed
  60. Golden TN, et al. 2022. Front Pharmacol. 12:761496. PubMed
  61. Cai C, et al. 2021. Sci Rep. 11:13386. PubMed
  62. Ruiz de Azua I, et al. 2017. J Clin Invest. 127:4148. PubMed
  63. Miura I, et al. 2021. Physiol Rep. 9:e14859. PubMed
  64. Li H, et al. 2021. Nat Commun. 12:7149. PubMed
  65. Germundson DL, et al. 2022. Front Allergy. 3:870513. PubMed
  66. Sztwiertnia I, et al. 2020. PLoS One. 15:e0233789. PubMed
  67. Liu C et al. 2019. Immunity. 51(2):381-397 . PubMed
  68. Chu SY, et al. 2019. Nat Commun. 10:1524. PubMed
  69. Shu Y, et al. 2020. Immunology. 160:345. PubMed
  70. Ying W, et al. 2016. Sci Rep. 6:20176. PubMed
  71. Anderson AE, et al. 2022. NPJ Regen Med. 7:6. PubMed
  72. Bhattacharya A, et al. 2018. Neuropsychopharmacology. 43:2586. PubMed
  73. Lu X, et al. 2012. Arterioscler Thromb Vasc Biol. 32:2358. PubMed
  74. Qiu N, et al. 2021. J Nanobiotechnology. 19:428. PubMed
  75. Yang C, et al. 2022. Nat Commun. 13:4866. PubMed
  76. Lu SW, et al. 2020. Nat Commun. 3.660416667. PubMed
  77. Lowe PP, et al. 2020. J Neuroinflammation. 0.913888889. PubMed
  78. Zhou K, et al. 2016. J Cereb Blood Flow Metab. 10.1177/0271678X16648712. PubMed
  79. Deng W, et al. 2015. Clin Immunol. . PubMed
  80. Anderson-Baucum E, et al. 2021. Cell Metab. 33:1883. PubMed
  81. Stevenson ER, et al. 2022. J Pharmacol Exp Ther. 382:356. PubMed
  82. Wang X, et al. 2022. J Biol Chem. 298:101561. PubMed
  83. Long L, et al. 2018. Bio Protoc. 8:e2815. PubMed
  84. Li C, et al. 2019. JCI Insight. 5. PubMed
  85. Asterholm I, et al. 2012. J Lipid Res. 53: 1254. PubMed
  86. Stridh L, et al. 2013. J Neurosci. 33:12401. PubMed
  87. Budai Z, et al. 2021. Cells. 10:. PubMed
  88. Zhu Q, et al. 2022. Atherosclerosis. 357:41. PubMed
  89. Krukowski K, et al. 2018. Sci Rep. 8:7857. PubMed
  90. Suzuki T, et al. 2017. Cell Rep. 18(8):2045-2057. PubMed
  91. Di Lorenzo A, et al. 2022. Oncoimmunology. 11:2086752. PubMed
  92. Li Y, et al. 2020. Theranostics. 10:2897. PubMed
  93. Leary N, et al. 2022. J Extracell Vesicles. 11:e12197. PubMed
  94. Zhang W, et al. 2021. Front Immunol. 12:768435. PubMed
  95. Ukah T, et al. 2017. J Immunol. 10.4049/jimmunol.1700410. PubMed
  96. Roediger B et al. 2018. Cell. 175(2):530-543 . PubMed
  97. Santopaolo M, et al. 2021. Front Immunol. 609406:12. PubMed
  98. Liu C, et al. 2022. Cell Death Discov. 8:269. PubMed
  99. Sears SM, et al. 2022. Kidney360. 3:818. PubMed
  100. Zhang J, et al. 2020. J Cell Mol Med. 24:4547. PubMed
  101. Budhu S, et al. 2021. Cell Reports. 34(2):108620. PubMed
  102. Srivastava S, et al. 2020. Cancer Cell. 39(2):193-208.e10. PubMed
  103. Browne A, et al. 2015. Cancer Res . 75: 2811 - 2821. PubMed
  104. Moreno M et al. 2014. The Journal of Neuroscience. 34(24):8175-85 . PubMed
  105. Lau P, et al. 2022. Cell Mol Immunol. :. PubMed
  106. Liu YS, et al. 2021. Cancers (Basel). 13:. PubMed
  107. Sadtler K, et al. 2017. Tissue Eng Part A. 23:1044. PubMed
  108. Li B et al. 2019. Cell reports. 26(10):2720-2737 . PubMed
  109. Morioka S, et al. 2018. Nature. 563:714. PubMed
  110. Mellal K, et al. 2019. Sci Rep. 9:12903. PubMed
  111. Yuan Y, et al. 2019. Clin Sci (Lond). 133:1759. PubMed
  112. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  113. Al-Zaeed N, et al. 2021. Cell Death Dis. 12:611. PubMed
  114. Golabek A, et al. 2021. Exp Ther Med. 21:482. PubMed
  115. Yeini E, et al. 2021. Nat Commun. 12:1912. PubMed
  116. Xu GY, et al. 2022. Small. 18:e2107838. PubMed
  117. Chuan Li et al. 2017. Endocrinology. 158(9):2837-2847 . PubMed
  118. Wen HJ, et al. 2019. Cell Mol Gastroenterol Hepatol. 8:p173. PubMed
  119. Yuan M, et al. 2017. Hum Reprod. 32:94. PubMed
  120. Riopel M, et al. 2019. Mol Metab. 20:89. PubMed
  121. Aurélien Trompette et al. 2018. Immunity. 48(5):992-1005 . PubMed
  122. Zheng H, et al. 2021. Frontiers in Immunology. 12:645100. PubMed
  123. Cai T, et al. 2022. Front Immunol. 13:1009932. PubMed
  124. Lal JC, et al. 2021. Breast Cancer Res. 23:83. PubMed
  125. Guo S, et al. 2021. Chronic Dis Transl Med. 7:254. PubMed
RRID
AB_10896421 (BioLegend Cat. No. 141705)
AB_10895754 (BioLegend Cat. No. 141706)

Antigen Details

Structure
Type I transmembrane protein, 175 kD, C-type lectin superfamily
Distribution

Macrophages, dendritic cells, Langerhans cells, liver endothelial cells

Function
Pathogen recognition, endocytosis and phagocytosis, antigen presentation
Ligand/Receptor
Antigen containing mannose, fucose, or an N-acetyl glucosamine
Cell Type
Dendritic cells, Endothelial cells, Langerhans cells, Macrophages
Biology Area
Cell Biology, Immunology, Innate Immunity, Signal Transduction
Molecular Family
CD Molecules
Antigen References

1. Wileman TE, et al. 1986. P. Natl. Acad. Sci. USA 83:2501.
2. Apostolopoulos V, et al. 2001. Curr. Mol. Med. 1:469.
3. Burgdorf S, et al. 2006. J. Immunol. 176:6770.
4. McKenzie EJ, et al. 2007. J. Immunol. 178:4975.

Gene ID
17533 View all products for this Gene ID
UniProt
View information about CD206 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Why is mouse CD206 stained intracellularly and not via surface staining?

Typically, mouse CD206 surface level is relatively low under normal conditions and so intracellular staining protocol is required to get better signal.

Go To Top Version: 3    Revision Date: 04-04-2016

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

BioLegend Inc., 8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Biotin anti-mouse CD206 (MMR)

  • Purified anti-mouse CD206 (MMR)

  • FITC anti-mouse CD206 (MMR)

  • PE anti-mouse CD206 (MMR)

  • APC anti-mouse CD206 (MMR)

  • Alexa Fluor® 488 anti-mouse CD206 (MMR)

  • Alexa Fluor® 647 anti-mouse CD206 (MMR)

  • PerCP/Cyanine5.5 anti-mouse CD206 (MMR)

  • PE/Cyanine7 anti-mouse CD206 (MMR)

  • Brilliant Violet 421™ anti-mouse CD206 (MMR)

  • Brilliant Violet 605™ anti-mouse CD206 (MMR)

  • Brilliant Violet 650™ anti-mouse CD206 (MMR)

  • Alexa Fluor® 594 anti-mouse CD206 (MMR)

  • Brilliant Violet 711™ anti-mouse CD206 (MMR)

  • Brilliant Violet 785™ anti-mouse CD206 (MMR)

  • PE/Dazzle™ 594 anti-mouse CD206 (MMR)

  • Alexa Fluor® 700 anti-mouse CD206 (MMR)

  • Spark YG™ 570 anti-mouse CD206 (MMR)

  • PE/Cyanine5 anti-mouse CD206 (MMR)

  • PE/Fire™ 700 anti-mouse CD206 (MMR)

ProductsHere

Login / Register
Remember me
Forgot your password? Reset password?
Create an Account