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PE anti-human CD105 Antibody

Pricing & Availability
Clone
43A3 (See other available formats)
Regulatory Status
RUO
Other Names
Endoglin
Isotype
Mouse IgG1, κ
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Product Citations
publications
43A3_PE_CD105_Antibody_FC_061715
Human mesenchymal stem cells were stained with CD105 (clone 43A3) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
  • 43A3_PE_CD105_Antibody_FC_061715
    Human mesenchymal stem cells were stained with CD105 (clone 43A3) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
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323205 25 tests 98€
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323206 100 tests 215€
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Description

CD105 is also known as Endoglin. It is a type I integral membrane homodimer protein with subunits of 90 kD found on vascular endothelial cells and syncytiotrophoblasts of placenta. CD105 is weakly expressed on stromal fibroblasts. It is also expressed on activated monocytes and tissue macrophages. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation. CD105 is a component of the TGF-β receptor system in human umbilical vein endothelial cells and binds TGF-β1 and β3 with high affinity but does not bind to TGF-β2.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
L-cells transfected with human CD105
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References
  1. Bühring HJ, et al. 1991. Leukemia 5:841.
  2. Vogel W, et al. 2002. Haematologica 88:126.
  3. Osaka M, et al. 2011. Brain Res. 9:1343. PubMed
  4. HonMou O, et al. 2011. Brain. 134:1790. PubMed
  5. Herrera MB, et al. 2013. Hepatology. 57:311. PubMed
  6. Iohara K, et al. 2014. Exp Gerontol. 52:39. PubMed
Product Citations
  1. Kim SW, et al. 2018. Adv Sci (Weinh). 5:1700860. PubMed
  2. Wu J, et al. 2020. Cell Res. 30:794. PubMed
  3. Park J, et al. 2021. Exp Ther Med. 22:808. PubMed
  4. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  5. Sonoda S, et al. 2022. STAR Protoc. 3:101386. PubMed
  6. Liu C, et al. 2022. Regen Ther. 21:192. PubMed
  7. Melzer C, et al. 2020. Int J Mol Sci. :21. PubMed
  8. Lee JK, et al. 2020. Sci Rep. 2.567361111. PubMed
  9. Liu X, et al. 2020. Exp Ther Med. 1.258333333. PubMed
  10. Shi L, et al. 2021. Stem Cell Res Ther. 12:147. PubMed
  11. Herrera M, et al. 2013. Hepatology. 57:311. PubMed
  12. Huang X, et al. 2019. Oxid Med Cell Longev. 2019:1305049. PubMed
  13. Kokkinopoulos I, et al. 2021. Sci Rep. 11:15759. PubMed
  14. Zhang B, et al. 2022. Stem Cells Int. 2022:2236250. PubMed
  15. Nowak WN, et al. 2019. Mediators Inflamm. 2019:1868170. PubMed
  16. Ali S, et al. 2018. Purinergic Signal. 14:371. PubMed
  17. Sun W, et al. 2019. Exp Ther Med. 17:2199. PubMed
  18. Panciera T, et al. 2016. Cell Stem Cell. 19:725-737. PubMed
  19. Liu W, et al. 2018. Theranostics. 8:5575. PubMed
  20. Zhang J, et al. 2022. Int J Mol Sci. 23:. PubMed
  21. Liu Y, et al. 2022. iScience. 25:104405. PubMed
  22. Schupp J, et al. 2021. Int J Mol Sci. 22:00. PubMed
  23. Lance R Thurlow et al. 2018. Journal of cellular biochemistry. 120(6):9213-9229 . PubMed
  24. Zhang Y, et al. 2019. Aging (Albany NY). 11:12641. PubMed
  25. Honmou O, et al. 2011. Brain. 134:1790. PubMed
  26. Lee JK, et al. 2021. Cells. 10:. PubMed
  27. Xu L, et al. 2022. Int J Mol Sci. 23:. PubMed
  28. Mithal A, et al. 2020. Nat Commun. 0.607638889. PubMed
  29. He H, et al. 2019. J Cell Mol Med. 23:4139. PubMed
  30. Wang W, et al. 2022. Int J Mol Sci. 23:. PubMed
  31. Labedz-Maslowska A, et al. 2020. Int J Mol Sci. 21:. PubMed
  32. Matheni C, et al. 2021. Cell J. 23:145. PubMed
  33. Iohara K, et al. 2014. Exp Gerontol. 52:39. PubMed
  34. Pan C, et al. 2019. Int J Mol Med. 44:1629. PubMed
  35. Hong Y, et al. 2020. Aging Cell. 19:e13128. PubMed
  36. Henson F, et al. 2021. J Orthop Res. 39:1411. PubMed
  37. Honmou O, et al. 2011. Brain. 1.307638889. PubMed
  38. Wang G, et al. 2018. Int J Mol Med. 41:791. PubMed
  39. Khanh VC, et al. 2021. Stem Cells Dev. 30:758. PubMed
RRID
AB_755957 (BioLegend Cat. No. 323205)
AB_755958 (BioLegend Cat. No. 323206)

Antigen Details

Structure
Associates with TGF-ß receptor I and II, homodimeric type I integral membrane protein, 90 kD
Distribution

Endothelial cells, activated monocytes/macrophages, bone marrow stromal cells, hematopoietic stem/progenitor cells

Function
Modulates cellular response to TGF-ß, involved in vascular development and remodelling
Ligand/Receptor
TGF-ß1, TGF-ß3
Cell Type
Endothelial cells, Hematopoietic stem and progenitors, Macrophages, Mesenchymal Stem Cells, Monocytes
Biology Area
Angiogenesis, Cell Biology, Immunology, Stem Cells
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Mason D, et al. Eds. 2002. Leucocyte Typing VII. Oxford University Press. New York.
2. Pierelli L, et al. 2001. Leuk. Lymphoma 42:1195.

Gene ID
2022 View all products for this Gene ID
UniProt
View information about CD105 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 06-17-2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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