- W15099A (See other available formats)
- Other Names
- TNFR-I, TNFRSF1A, P55, P60
- Mouse IgG2a, κ
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- Product Citations
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CD120a, also known as tumor necrosis factor receptor type 1 (TNF-R1) is 55 kD member of tumor necrosis receptor superfamily (TNFRSF) which which upon binding tumor necrosis factor alpha (TNF-α), homotrimerizes to interact death domain of TRADD. CD120a, in association with TRADD, leads to activation of NF-κB signaling, in addition to apoptotic and inflammatory responses.Product Details
- Antibody Type
- Host Species
- Full length human CD120a transfectant cells.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2650932 (BioLegend Cat. No. 369908)
- 55 kD, single pass type 1 membrane protein, TNFR superfamily.
Granulocytes, monocytes, and lymphocytes.
- Homotrimerizes upon binding TNF, activates apoptotic and NF-κB signaling.
- TNF-α, LTα (TNF-β)
- Cell Type
- Granulocytes, Monocytes, Lymphocytes, Neutrophils, Eosinophils
- Biology Area
- Molecular Family
- CD Molecules
- Antigen References
1. Loetscher H, et al. 1990. Proc. Natl. Acad. Sci. USA 87:3127.
2. Crowe PD, et al. 1994. J. Immunol. 264:707.
3. Aggarwal BB, et al. 1985. J. Biol. Chem. 260:2345.
4. Chan FK, et al. 2000. Science. 288:2351.
5. Sugano M, et al. 2002. Atherosclerosis 162:77.
6. Cottin V, et al. 2002. J. Immunol. 168:4095.
7. Barnhart BC, Peter ME. 2003. Cell. 114:148.
- Gene ID
- 7132 View all products for this Gene ID
- View information about CD120a on UniProt.org
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
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