APC anti-human CD201 (EPCR) Antibody

Pricing & Availability
RCR-401 (See other available formats)
Regulatory Status
Other Names
Endothelial protein C receptor, protein C receptor, PROCR, activated protein C receptor, APC receptor
Rat IgG1, κ
Ave. Rating
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Product Citations
HUVEC cells were stained with CD201 (clone RCR-401) APC (filled histogram) or rat IgG1, κ APC isotype control (open histogram).
  • RCR-401_APC_020712
    HUVEC cells were stained with CD201 (clone RCR-401) APC (filled histogram) or rat IgG1, κ APC isotype control (open histogram).
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351905 25 tests 91€
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351906 100 tests 247€
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Endothelial protein C receptor (EPCR), also known as CD201, is a 46 kD N-glycosylated type I transmembrane protein primarily expressed on the endothelial cells of arteries and veins in heart and lung. It is also expressed at high levels on a subset of hematopoietic stem cells and a subset of dendritic cells. CD201 functions as a primary receptor for protein C activation, which results in inhibition of both intrinsic and extrinsic coagulation pathways. It also plays an important role in many pathophysiologic processes, such as inflammation responses to infection, trauma, hematopoiesis, and autoimmune response. Deletion of the CD201 gene in knock-out mice leads to embryonic lethality before embryonic day 10, indicating that CD201 expression is critical for embryo development. In humans, mutations of CD201 have been associated with venous thromboembolism and myocardial infarction as well as with late fetal loss during pregnancy.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Antibody Type
Host Species
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Product Citations
  1. Chagraoui J, et al. 2021. Cell Stem Cell. 28(1):48-62.e6. PubMed
AB_11142684 (BioLegend Cat. No. 351905)
AB_11126139 (BioLegend Cat. No. 351906)

Antigen Details

46 kD of N-glycosylated type I transmembrane protein

Endothelial cells, subset of hematopoietic stem cells, subset of dendritic cells

Inhibits blood coagulation, inflammation, and hematopoiesis
Activated receptor1 (Par-1)
Protease C
Cell Type
Dendritic cells, Endothelial cells, Hematopoietic stem and progenitors
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. Kerschen E, et al. 2010. J. Clin. Invest. 120:3167.
2. Iwasaki H, et al. 2010. Blood 116:544.
3. Balazs AB, et al. 2006. Blood 107:2317.

Gene ID
10544 View all products for this Gene ID
View information about CD201 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11-30-2012

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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