- A18196A (See other available formats)
- Regulatory Status
- Other Names
- Ubiquitin-conjugating enzyme E2 variant 1, UEV-1, CROC-1, TRAF6-regulated IKK activator 1 beta Uev1A
- Mouse IgG2a, κ
- Ave. Rating
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- Product Citations
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Ubiquitination is a common post-translational modification of proteins and plays an important role in protein homeostasis. UBE2V1 encodes one of the ubiquitin-conjugating E2 enzyme variant proteins (UBE2V), which lacks the conserved cysteine residue required for the catalytic activity of E2s. Elevated expression of UBE2V1 has been associated with tumor development; however, it is not clear whether it functions as an oncogene or tumor suppressor gene. In addition, UBE2V1 is a key component in TRAF6 to control NF-κB activation.Product Details
- Verified Reactivity
- Human, Mouse, Rat, Drosophila
- Antibody Type
- Host Species
- Recombinant human UBE2V1 protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 1.0 - 10 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2832874 (BioLegend Cat. No. 870701)
AB_2832875 (BioLegend Cat. No. 870702)
- Human UBE2V1 is a 147 amino acid protein with a predicted molecular mass of 16 kD.
Tissue distribution: Ubiquitously expressed
Cellular distribution: Cytosol, nucleus
- UBE2V1 is a ubiquitin-conjugating enzyme.
- Cell Type
- Astrocytes, Neurons
- Biology Area
- Cell Biology, Cell Cycle/DNA Replication, Neuroinflammation, Neuroscience, Protein Trafficking and Clearance, Ubiquitin/Protein Degradation
- Molecular Family
- Enzymes and Regulators, Ligases
- Antigen References
- Ma L, et al. 1998. Oncogene. 17:1321-6.
- Shen T, et al. 2018. J. Hematol. Oncol. 11:95.
- Wu X, Karin M. 2015. Immunol. Rev. 266:161-74.
- Gene ID
- 7335 View all products for this Gene ID
- View information about UBE2V1 on UniProt.org
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