- SP17 (See other available formats)
- Regulatory Status
- Other Names
- SYP, Synaptophysin, Major synaptic vesicle protein P38
- Mouse IgM, κ
- Ave. Rating
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- Product Citations
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Synaptophysin, also known as major synaptic vesicle protein P38, is encoded by the SYP gene in humans and is located on the short arm of the X chromosome. Synaptophysin is expressed in neuroendocrine cells as well as all neurons in the CNS that participate in synaptic transmission. Synaptophysin is a synaptic vesicle glycoprotein, and interacts with synaptobrevin. It has been implicated in X-linked mental retardation and can be used as a specific marker for cells of the adrenal medulla and pancreatic islets. As such, it can be used to identify tumors that are derived from those cells, including neuroblastoma, retinoblastoma, medulloblastoma, and others.Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Host Species
- This antibody was raised against a crude synaptic preparation from post mortem human brain.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
ICC, IHC-P - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 10 µg per mL. For immunocytochemistry, a concentration range of 1.0 - 10 μg/mL is recommended. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 10 µg/mL for chromogenic staining and 0.5 - 2.0 µg/mL for fluorescent staining is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
SP17 reacts with native, denatured and recombinant synaptic vesicle protein synaptophysin expressed in CHO cells. The antibody is particularly valuable for immunocytochemical studies of the brain due to its stability in formalin sections.
- Application References
- Product Citations
AB_2783410 (BioLegend Cat. No. 837103)
AB_2783411 (BioLegend Cat. No. 837104)
- Synaptophysin is a 313 amino acid protein with an apparent molecular mass of 34 kD.
Tissue distribution: Brain, pancreas, adipose and soft tissue, gastrointestinal tract, bone marrow, and immune system.
Cellular Distribution: Plasma and synaptic vesicle membrane.
- Synaptophysin plays a role in synaptic vesicle docking and membrane fusion.
- SRCIN1, also interact with itself to form homohexamer or homotetramer
- Biology Area
- Cell Biology, Neuroscience, Synaptic Biology
- Molecular Family
- Presynaptic proteins
- Antigen References
- Zhang L, et al. 2018. Medicine (Baltimore). 97(29):e11487
- Moris, et al. 2018. Anticancer res. 38(2):601
- Hami J, et al. 2017. J pediatr Neurosci. 12(3):215
- Gene ID
- 6855 View all products for this Gene ID
- View information about Synaptophysin on UniProt.org
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