- 10F7 (See other available formats)
- Regulatory Status
- Other Names
- FUS, TLS
- Mouse IgG1, κ
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- Product Citations
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FUS/TLS is an RNA-binding protein that was originally discovered as a fusion protein caused by chromosomal translocation in cancer. FUS/TLS is as an important member of the cellular DNA repair response. The C-terminal end of FUS is involved in protein and RNA binding, while the N-terminal motif of FUS plays a role in transcriptional activation. FUS was also shown to accumulate in the cytoplasm of neurons under hyperosmotic conditions, and FUS mislocalization has been implicated as being the first step toward disease.Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Human TLS/FUS recombinant protein fused with GST tag.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2750473 (BioLegend Cat. No. 855001)
AB_2750474 (BioLegend Cat. No. 855002)
- FUS is a 526 amino acid protein with an apparent molecular mass of ~ 53 kD.
Tissue Distribution: Ubiquitously expressed
Cellular Distribution: Nucleus and cytosol
- FUS/TLS binds to DNA and maintains genomic integrity.
- Interacts with HDAC1, RNA Polymerase II, FUSIP1, ILF3, PRMT1, RELA, SPI1, and TNPO1.
- Cell Type
- Astrocytes, Neurons, Oligodendrocytes
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation, Synaptic Biology
- Molecular Family
- Postsynaptic proteins, Presynaptic proteins
- Antigen References
- Efimova AD, et al. 2017. Mol Biol (Mosk) 51:387.
- Ederle H, Dormann D. 2017. FEBS Lett. 591:1489.
- Guerrero EN, et al. 2016. Prog. Neurobiol. 145-146:78.
- Gene ID
- 2521 View all products for this Gene ID 233908 View all products for this Gene ID 217385 View all products for this Gene ID
- View information about FUS on UniProt.org
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