- W15111A (See other available formats)
- Other Names
- Forkhead box O3, FKHRL1, FOXO3A
- Mouse IgG2a, κ
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- Product Citations
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The Fork-head box O (FOXO) family of transcription factors is comprised of four family members; FOXO1, FOXO3, FOXO4, and FOXO6. FOXO3 was originally identified as a tumor suppressor and has been shown to regulate several cellular processes, such as cell cycle arrest, apoptosis, autophagy, longevity, and stress response. FOXO3 activity is determined by its post-translational modifications and subcellular localization. FOXO3 is inactivated by cytoplasmic retension through AKT/PI3K signaling pathways. FOXO3 inactivation has been associated with cell proliferation and tumorigenesis. In contrast, over-expression of FOXO3 leads to inhibition of tumor growth. FOXO3 also plays an important role in the development of regulatory T cells. FOXO3-deficient mice showed organ inflammation phenotype and increased production of proinflammatory cytokines during viral infection.Product Details
- Human, Mouse
- Antibody Type
- Host Species
- Human FOXO3 recombinant protein (424-673 a.a.) expressed in E. coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
KO/KD-WB - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2616882 (BioLegend Cat. No. 686302)
- 673 amino acids with a predicted molecular weight of 71.3 kD. Contains a fork-head domain responsible for DNA binding.
Cytoplasm and nucleus.
- FOXO3 is a transcription factor, participating in the regulation of cell cycle arrest, apoptosis, autophagy, longevity, and stress response.
- Interacts with SIRT2, 14-3-3 beta, 14-3-3 zeta, STK4, PIM1, and DDIT3.
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Transcription Factors
- Molecular Family
- Nuclear Markers
- Antigen References
1. Morris BJ, et al. 2015. Gerontology 61:515.
2. Larsen SK, et al. 2014. Oncoimmunology 3:e953411.
3. Eijkelenboom A, et al. 2013. Cell Rep. 5:1664.
4. Yeo H, et al. 2013. EMBO J. 32:2589.
5. Pelosi E, et al. 2013. Nat. Commun. 4:1843.
6. Litvak V, et al. 2012. Nature 490:421.
- Gene ID
- 2309 View all products for this Gene ID
- View information about FOXO3 on UniProt.org
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