Purified anti-CCL11 Antibody

Pricing & Availability
Clone
L403H11 (See other available formats)
Other Names
Eotaxin, eotaxin-1, small inducible cytokine subfamily A, member 11 (SCYA11)
Isotype
Rat IgG1, κ
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Product Citations
publications
Cat # Size Price Quantity Avail. Save
683202 500 µg 200€
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Description

CCL11 is a member of the CC chemokine family. It was originally identified as a chemoattractant for eosinophils, and participates in a variety of allergic responses to allergens. CCL11 induces angiogenic responses in CCR3+ microvascular endothelial cells and facilitates the proliferation and metastasis of CCR3+ tumor cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant Mouse CCL11, (amino acids (His24-Pro97, Accession# NM_011330), were expressed in E. coli.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

ELISA Capture - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by ELISA. For ELISA capture applications, a concentration of 0.5 µg/mL is recommended. To obtain a linear standard curve, serial dilutions of CCL11 recombinant protein ranging from 500 to 7.81 pg/mL are recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance.

RRID
AB_2686953 (BioLegend Cat. No. 683202)

Antigen Details

Structure
Chemokine
Distribution

Epithelial cells, smooth muscle cells, dendritic cells, fibroblasts, mast cells, and Th2 lymphocytes.

Function
Recruits eosinophils in allergic responses. Stimulates eosinophil release from bone marrow, increasing levels of circulating eosinophils. Induced by pro-inflammatory cytokines (IL-4, IL-13, TNF-7alpha;, and IFN-α).
Interaction
Eosinophils
Ligand/Receptor
CCR3
Cell Type
Epithelial cells, Dendritic cells, Fibroblasts, Mast cells, Th2, Eosinophils
Biology Area
Angiogenesis, Cell Biology, Immunology, Neuroinflammation, Neuroscience
Molecular Family
Cytokines/Chemokines
Antigen References

1. Crump MP, et al. 1998. J. Biol. Chem. 273:22471.
2. Conroy DM, et al. 2001. Respir. Res. 2:150.
3. Salcedo R, et al. 2001. J. Immunol. 166:7571.
4. Hadjicharalambous C, et al. 2004. J. Allergy Clin. Immunol. 113:657.
5. Kaehler J, et al. 2006. J. Investig. Med. 54:446.
6. Levina V, et al. 2009. Clin. Cancer Res. 15:2647.

Gene ID
20292 View all products for this Gene ID
UniProt
View information about CCL11 on UniProt.org

Related FAQs

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