- W17010B (See other available formats)
- Other Names
- Interleukin 13
- Rat IgG1, κ
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- Product Citations
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Mouse IL-13 was initially cloned from cDNA libraries of activated T cells and was designated as P600. IL-13 is an immunoregulatory cytokine secreted predominantly by activated Th2 cells, and it is a key mediator in the pathogenesis of allergic inflammation. IL-13 shares many functional properties with IL-4, and they share a common receptor subunit, the alpha subunit of the IL-4 receptor (IL-4Ra). IL-13 mediates its effects by interacting with a complex receptor system comprised of IL-4Ra and two IL-13 binding proteins, IL-13Ralpha1 and IL-13Ralpha2. Ligation of the IL-13 receptor complex results in signaling via the insulin receptor substrate (IRS)-1 and 2 and STAT-6 pathways. IL-13 has been implicated in inflammatory responses, such as airway hypersensitivity and mucus hypersecretion, inflammatory bowel disease, and parasitic nematode expulsion.Product Details
- Antibody Type
- Host Species
- Recombinant mouse IL-13
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.06 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
AB_2832569 (BioLegend Cat. No. 159403)
Th2 cells, basophils, mast cells, activated eosinophils and NK cells
- IL-13 modulates mouse monocytes/macrophages and B cells. IL-13 induces an increase of MHC class II expression in mouse monocytes/macrophages, and direct inhibition of inflammatory cytokines such as TNF-α and IL-1β.
- IL-4Rα, IL-13Rα1, and IL-13Rα2
- Cell Type
- Basophils, Eosinophils, Mast cells, NK cells, Th2
- Biology Area
- Molecular Family
- Antigen References
- Brown KD, et al. 1989. J Immunol. 142:679-87.
- McKenzie AN, et al. 1993. Proc Natl Acad Sci USA. 90:3735-9.
- McKenzie GJ, et al. 1999. J Exp Med. 189:1565-72.
- Gene ID
- 16163 View all products for this Gene ID
- View information about IL-13 on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
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