- 8F9 (See other available formats)
- HCDM listed
- Other Names
- C-type lectin family member 9A, CD370
- Mouse IgG2a, κ
- Ave. Rating
- 1 reviews
- Product Citations
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CD370 (CLEC9A), also known as DNGR1, is a type II transmembrane protein consisting of a single extracellular C-type lectin domain (CTLD) that is connected to the transmembrane domain by a stalk region, and an intracellular cytoplasmic tail with immunoreceptor tyrosine-based activation motif (ITAM). In humans, CLEC9A is strictly expressed on BDCA3-positive conventional dendritic cells (cDC) and CD16- monocytes. CLEC9A recognizes a ubiquitous preformed acid-labile protein associated ligand(s) that is exposed on necrotic cells. CLEC9A ligation is necessary for efficient cross-presentation of dead-cell-associated antigen by recruitment and activation of the tyrosine kinase Syk.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Product Citations
AB_10959651 (BioLegend Cat. No. 353803)
AB_10965546 (BioLegend Cat. No. 353804)
- Type II transmembrane glycoprotein; consists of a 35 amino acid (aa) cytoplasmic domain with an ITAM like motif, a 21 aa transmembrane segment, a 185 aa extracellular domain (ECD) that contains a stalk region, and one C-type lectin domain (CTLD).
Dendritic subsets including plasmacytoid dendritic cells.
- Cross-present antigen to CTL, phagocytosis necrotic cells.
- Necrotic cells.
- Ubiquitous preformed acid-labile protein associated ligand(s).
- Cell Type
- Dendritic cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules, MHC Antigens
- Antigen References
1. Poulin LF, et al. 2010. J. Exp. Med. 207:1261.
2. Sancho D, et al. 2009. Nature 458:899.
3. Huysamen C, et al. 2008. J. Biol. Chem. 283:16693.
- Gene ID
- 283420 View all products for this Gene ID
- View information about CD370 on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
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