- SP12 (See other available formats)
- Regulatory Status
- Other Names
- Synaptosomal-associated protein 25, SUP, RIC-4, RIC4, SEC9, SNAP
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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SNAP-25, also known as synaptosomal-associated protein 25, is a component of the trans-SNARE complex. It is a Q-SNARE protein anchored to the membrane on the cytosolic face, and does not contain a trans-membrane domain. The SNARE complex is involved in the vesicle fusion process. SNAP-25 is implicated in the inhibition of voltage-gated calcium channels, and has been shown to decrease calcium responsiveness in glutamatergic synapses.Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Host Species
- This antibody was raised against a crude synaptic preparation from the post mortem human brain.
- This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
- The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
- 0.5 mg/mL
- Storage & Handling
- Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
WB - Quality tested
IHC-P - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.001 - 0.02 µg/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 0.5 - 2.0 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
- Honer WG, et al. 1993. Brain Res. 609:9-20.
- Brinkmalm A, et al. 2014. Mol. Neurodegener. 9:53. (IP) PubMed
AB_2820123 (BioLegend Cat. No. 805003)
AB_2820124 (BioLegend Cat. No. 805004)
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