HRP anti-HNRNPA1 Antibody, HNRNPA1, 4B10/HNRNPA1

Pricing & Availability

Clone: 4B10/HNRNPA1 (See other available formats)
Regulatory Status: RUO
Other Names: Heterogeneous nuclear ribonucleoprotein A1, hnRNP A1, Helix-destabilizing protein, Single-strand RNA-binding protein, hnRNP core protein A1
Isotype: Mouse IgG2a, κ
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Product Citations: publications

Western blot of HRP anti-HNRNPA1 antibody (clone 4B10/HNRNPA1). Lane 1: Molecular weight marker; Lane 2: 20 µg of human brain lysate; Lane 3: 20 µg of mouse brain lysate; Lane 4: 20 µg of rat brain lysate. The blot was incubated with 0.5 µg/mL of the primary antibody overnight at 4°C. Enhanced chemiluminescence was used as the detection system.

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862503

25 µg

113€

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862504

100 µg

249€

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Description

Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a multi-purpose RNA binding protein involved in RNA metabolism and DNA genomic stability in normal and pathological conditions. hnRNP A1 is ubiquitously expressed and usually associates with nascent RNA polymerase II transcripts. hnRNP A1 is abundantly expressed in neuronal cells and reproductive tissue. Loss of hnRNP A1 has been observed in several neurodegenerative diseases, including Alzheimer’s disease, multiple sclerosis, amytrophic lateral sclerosis. Structurally, hnRNPA1 has two RNA recognition motifs, which are post-translationally modified to alter its nuclear pore shuttling properties and RNA interaction.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Human, Mouse, Rat
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Partially purified HeLa HNRNPA1 protein
Formulation: This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
Preparation: The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
Concentration: 0.5 mg/ml
Storage & Handling: Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
Application: WB - Quality tested
IHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 1.0 µg per ml. For formalin-fixed paraffin-embedded immunohistochemical staining, a concentration range of 2 - 5 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2810751 (BioLegend Cat. No. 862503)
AB_2810752 (BioLegend Cat. No. 862504)

Antigen Details

Structure

hnRNPA1 has two isoforms. Human HNRPNA1 isoform A1-A is a 320 amino acid protein with a molecular mass of 34 kD, and isoform A1-B is a 372 amino acid protein with a molecular mass of 38 kD.

Distribution

Tissue Distribution: Ubiquitous expression
Cellular Source: Nucleus and cytoplasm

Function

RNA metabolism, genomic stability

Interaction

Nascent RNA polymerase II transcripts

Cell Type

Neurons

Biology Area

Neurodegeneration, Neuroscience, Protein Synthesis

Antigen References

Bekenstein U, et al. 2013. Mol Cell Neurosci. 56:436-46.
Jean-Philippe J, et al. 2014. Biochim Biophys Acta. 1839(4): 251–258.

Gene ID

3178 View all products for this Gene ID 15382 View all products for this Gene ID 29578 View all products for this Gene ID

UniProt

View information about HNRNPA1 on UniProt.org

Documentation

Reviews

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Related Protocols

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Description	Clone	Applications

Related Pages & Pathways

Pathways

Neurodegeneration

Related FAQs

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Other Formats

View All HNRNPA1 Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-HNRNPA1	4B10/HNRNPA1	WB,IHC-P
HRP anti-HNRNPA1	4B10/HNRNPA1	WB,IHC-P
Biotin anti-HNRNPA1	4B10/HNRNPA1	IHC-P
Alexa Fluor® 488 anti-HNRNPA1	4B10/HNRNPA1	IHC-P
Alexa Fluor® 594 anti-HNRNPA1	4B10/HNRNPA1	IHC-P
Alexa Fluor® 647 anti-HNRNPA1	4B10/HNRNPA1	IHC-P

Certificate of Analysis

Go To Top Version: 1 Revision Date: 06/24/2019

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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