Myeloid-Derived Suppressor Cells

To protect the host from the harmful effects of excessive immune stimulation during acute and chronic infections and autoimmunity, the bone marrow is stimulated to release immature myeloid cells (IMCs) into the blood. These IMCs and some of their progeny, which may include tumor-associated macrophages, can restrain the activation of T cells. These myeloid-derived suppressor cells (MDSCs) to share a common myeloid origin and immunoregulatory properties. Tumors have evolved to ‘harness’ these MDSCs to restrain anti-tumor immunity and to promote tumor expansion through angiogenesis and metastasis.

 

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